4.7 Article

Selection and characterisation of bioreceptors to develop nanoparticle-based lateral-flow immunoassays in the context of the SARS-CoV-2 outbreak

Journal

LAB ON A CHIP
Volume 22, Issue 16, Pages 2938-2943

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d2lc00486k

Keywords

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Funding

  1. Consejo Superior de Investigaciones Cientificas (CSIC)
  2. European Union's Horizon 2020 research and innovation programme [825694]
  3. EU Graphene Flagship Core 3 Project [881603]
  4. CERCA programme/Generalitat de Catalunya
  5. Severo Ochoa Centres of Excellence programme - Spanish Research Agency (AEI) [SEV-20170706]
  6. Ministerio de Ciencia e Innovacion of Spain
  7. Fondo Social Europeo [PRE2018-084856]
  8. Autonomous University of Barcelona (UAB)
  9. Spanish Ministry of Science and Innovation
  10. State Research Agency through the Centro de Excelencia Severo Ochoa 2019-2023 Program [CEX2018-000806-S]
  11. Generalitat de Catalunya through the CERCA Program
  12. PROBIST postdoctoral fellowship - European Research Council [754510]
  13. H2020 Societal Challenges Programme [825694] Funding Source: H2020 Societal Challenges Programme

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This manuscript highlights the importance of better characterised bioreceptors for the development of point-of-care diagnostic devices. The challenges faced in finding suitable antibodies for the detection of SARS-CoV-2 nucleoprotein in a lateral flow assay are discussed.
This manuscript aims at raising the attention of the scientific community to the need for better characterised bioreceptors for fast development of point-of-care diagnostic devices able to support mass frequency testing. Particularly, we present the difficulties encountered in finding suitable antibodies for the development of a lateral flow assay for detecting the nucleoprotein of SARS-CoV-2.

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