4.5 Article

SRV-GAN: A generative adversarial network for segmenting retinal

Journal

MATHEMATICAL BIOSCIENCES AND ENGINEERING
Volume 19, Issue 10, Pages 9948-9965

Publisher

AMER INST MATHEMATICAL SCIENCES-AIMS
DOI: 10.3934/mbe.2022464

Keywords

deep learning; retinal image segmentation; generative adversarial networks; attention; loss functions

Funding

  1. National Natural Science Foundation of China [61672386]
  2. Anhui Provincial Natural Science Foundation of China [1708085MF142]
  3. Key Research and Development Plan of Anhui Province, China [2022a05020011]

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This paper proposes an improved generative adversarial network model for retinal blood vessel segmentation, which utilizes attention mechanisms and dense connection modules to enhance segmentation performance. The experimental results demonstrate that this method achieves high accuracy in retinal blood vessel pixel segmentation on three public datasets.
In the field of ophthalmology, retinal diseases are often accompanied by complications, and effective segmentation of retinal blood vessels is an important condition for judging retinal diseases. Therefore, this paper proposes a segmentation model for retinal blood vessel segmentation. Generative adversarial networks (GANs) have been used for image semantic segmentation and show good performance. So, this paper proposes an improved GAN. Based on R2U-Net, the generator adds an attention mechanism, channel and spatial attention, which can reduce the loss of information and extract more effective features. We use dense connection modules in the discriminator. The dense connection module has the characteristics of alleviating gradient disappearance and realizing feature reuse. After a certain amount of iterative training, the generated prediction map and label map can be distinguished. Based on the loss function in the traditional GAN, we introduce the mean squared error. By using this loss, we ensure that the synthetic images contain more realistic blood vessel structures. The values of area under the curve (AUC) in the retinal blood vessel pixel segmentation of the three public data sets DRIVE, CHASE-DB1 and STARE of the proposed method are 0.9869, 0.9894 and 0.9885, respectively. The indicators of this experiment have improved compared to previous methods.

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