Journal
COMPTES RENDUS CHIMIE
Volume 18, Issue 12, Pages 1313-1319Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crci.2015.07.008
Keywords
Ruthenium; Biological activity; Mass spectrometry; Carboxylate ligands; Phosphane ligands; X-Ray diffraction
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Funding
- FAPESP [2009/54011-8]
- FAPEMIG [APQ-04010-10]
- CNPq [2009/54011-8]
- CAPES [2009/54011-8]
- Minas Chemical Network (RQ-MG) [APQ-04010-10]
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The complex [Ru(eta(2)-O2CCH2CH3)(dPPe)(2)]PF6 (dppe = 1,2-bis(diphenylphosphino)ethane) was prepared and characterized by elemental analysis, spectroscopic techniques, X-ray crystallography, HRESIMS and HRESIMS/MS. The characterization data are consistent with a cis arrangement for the dppe ligands and a bidentate coordination of the propionate ligand through carboxylate oxygens. Cytotoxicity assays were carried out on human and murine cancer and normal cell lines. In general, the [Ru(eta(2)-O2CCH2CH3)(dPPe)(2)]PF6 complex was more cytotoxic than both its precursor cis-[RuCl2(dppe)(2)] and the reference metallodrug cisplatin. The best results against the HepG2 human tumour cell line and S180 murine tumour cell line were found with IC50 values of 6.5 +/- 0.2 and 0.18 +/- 0.03 mu M respectively. (C) 2015 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
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