Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 65, Pages 9136-9139Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc02789e
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Funding
- National Natural Science Foundation of China [22174058]
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In this study, a novel fluorescent probe was developed for the detection of H2S. The probe showed comparable imaging performance to the traditional probe but exhibited lower toxicity to cells and animals.
During biological detection, the toxicity caused by probes to living organisms is neglected. In this study, an analyte-compensated fluorescent probe (NP-SN3) was constructed for the detection of H2S. Through experiments with HepG2 cells and zebrafish embryos and larvae, the NP-SN3 probe showed no significant difference in imaging performance compared with the traditional probe (NP-N-3) but exhibited lower detection-induced toxicity in the imaging of liver fibrosis in activated HSC-T6 cells. During the development of zebrafish embryos and continuous administration in rats, NP-SN3 showed a lower death rate, higher hatchability and lower malformation in zebrafish embryos and milder pathological symptoms in stained rat tissues.
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