☆ 4.6 Review

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

JOURNAL OF MATERIALS CHEMISTRY B (2022)

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Implications of the Human Gut-Brain and Gut-Cancer Axes for Future Nanomedicine

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Transport of artificial virus-like nanocarriers through intestinal monolayers via microfold cells

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Extracellular vesicles containing miR-146a attenuate experimental colitis by targeting TRAF6 and IRAK1

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Cellular and Molecular Therapeutic Targets in Inflammatory Bowel Disease-Focusing on Intestinal Barrier Function

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Nanoparticles: Oral Delivery for Protein and Peptide Drugs

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Mucus and mucins in diseases of the intestinal and respiratory tracts

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Therapeutic effect of gold nanoparticles on DSS-induced ulcerative colitis in mice with reference to interleukin-17 expression

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Multi-bioresponsive silk fibroin-based nanoparticles with on-demand cytoplasmic drug release capacity for CD44-targeted alleviation of ulcerative colitis

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An Orally Administrated Hyaluronan Functionalized Polymeric Hybrid Nanoparticle System for Colon-Specific Drug Delivery

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Oral administration of chondroitin sulfate-functionalized nanoparticles for colonic macrophage-targeted drug delivery

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Nanoparticle-Mediated Drug Delivery Systems For The Treatment Of IBD: Current Perspectives

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Oral Drug Delivery Systems for Ulcerative Colitis Therapy: A Comparative Study with Microparticles and Nanoparticles

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CURRENT CANCER DRUG TARGETS (2019)

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Microbial network disturbances in relapsing refractory Crohn's disease

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Gut microbiome structure and metabolic activity in inflammatory bowel disease

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Depletion of activated macrophages with a folate receptor-beta-specific antibody improves symptoms in mouse models of rheumatoid arthritis

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Intestinal organoids containing poly(lactic-co-glycolic acid) nanoparticles for the treatment of inflammatory bowel diseases

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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2018)

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Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis

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Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

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Colon-targeted dexamethasone microcrystals with pH-sensitive chitosan/alginate/Eudragit S multilayers for the treatment of inflammatory bowel disease

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Process, optimization, and characterization of budesonide-loaded nanostructured lipid carriers for the treatment of inflammatory bowel disease

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Inflamed site-specific drug delivery system based on the interaction of human serum albumin nanoparticles with myeloperoxidase in a murine model of experimental colitis

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Biodistribution and targeting potential assessment of mucoadhesive chitosan nanoparticles designed for ulcerative colitis via scintigraphy

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Surface engineered lipid nanoparticle-mediated site-specific drug delivery system for the treatment of inflammatory bowel disease

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The antioxidant Procyanidin reduces Reactive Oxygen Species Signaling in Macrophages and Ameliorates Experimental Colitis in Mice

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Promising therapeutic effect of gold nanoparticles against dinitrobenzene sulfonic acid-induced colitis in rats

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Preparation and characterization of pH-sensitive nanoparticles of budesonide for the treatment of ulcerative colitis

Hong Zhou et al.

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A systematic review of nano formulation of natural products for the treatment of inflammatory bowel disease: drug delivery and pharmacological targets

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Synthesis and evaluation of anti-inflammatory properties of silver nanoparticle suspensions in experimental colitis in mice

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In vitro study on anti-inflammatory effects of epigallocatechin-3-gallate-loaded nano- and microscale particles

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Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase

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Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease

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Ultra-small solid archaeolipid nanoparticles for active targeting to macrophages of the inflamed mucosa

Leticia Herminia Higa et al.

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Oral administration of ginger-derived nanolipids loaded with siRNA as a novel approach for efficient siRNA drug delivery to treat ulcerative colitis

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Discrimination between ulcerative colitis and Crohn's disease using phage display identified peptides and virus-mimicking synthetic nanoparticles

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Solid lipid nanoparticles delivering anti- inflammatory drugs to treat inflammatory bowel disease: Effects in an in vivo model

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The intestinal barrier: a fundamental role in health and disease

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pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms

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Bioengineering Bacterially Derived Immunomodulants: A Therapeutic Approach to Inflammatory Bowel Disease

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Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation

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Dysbiosis and the immune system

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Size-dependent nanoparticulate drug delivery in inflammatory bowel diseases

John Youshia et al.

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Budesonide Loaded PLGA Nanoparticles for Targeting the Inflamed Intestinal Mucosa-Pharmaceutical Characterization and Fluorescence Imaging

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Self assembled hyaluronic acid nanoparticles as a potential carrier for targeting the inflamed intestinal mucosa

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Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

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Targeting Inflammatory Bowel Diseases by Nanocarriers Loaded with Small and Biopharmaceutical Anti-Inflammatory Drugs

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Effect of particle size on their accumulation in an inflammatory lesion in a dextran sulfate sodium (DSS)-induced colitis model

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Role of nanoparticle size, shape and surface chemistry in oral drug delivery

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INNATE IMMUNITY A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

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Anthony Cheung et al.

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Combination Therapy for Ulcerative Colitis: Orally Targeted Nanoparticles Prevent Mucosal Damage and Relieve Inflammation

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Non-genetic engineering of cells for drug delivery and cell-based therapy

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Polymeric nanoparticle drug delivery technologies for oral delivery applications

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Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair

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Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap® System

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Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut

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Transepithelial Transport of PAMAM Dendrimers Across Isolated Human Intestinal Tissue

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Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

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TLR5-Mediated Sensing of Gut Microbiota Is Necessary for Antibody Responses to Seasonal Influenza Vaccination

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Fate of nanostructured lipid carriers (NLCs) following the oral route: design, pharmacokinetics and biodistribution

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pH-Sensitive Nanoparticles of Curcumin-Celecoxib Combination: Evaluating Drug Synergy in Ulcerative Colitis Model

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Targeted Drug Delivery to Intestinal Macrophages by Bioactive Nanovesicles Released from Grapefruit

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Enteric glial cells and their role in the intestinal epithelial barrier

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Glycoprotein CD98 as a receptor for colitis-targeted delivery of nanoparticles

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Mannosylated bioreducible nanoparticle-mediated macrophage-specific TNF-α RNA interference for IBD therapy

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Eudragit (R): a technology evaluation

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Budesonide-loaded nanostructured lipid carriers reduce inflammation in murine DSS-induced colitis

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Drug delivery to inflamed colon by nanoparticles: Comparison of different strategies

Regis Coco et al.

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Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

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Transepithelial transport and toxicity of PAMAM dendrimers: Implications for oral drug delivery

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An Orally Administered Redox Nanoparticle That Accumulates in the Colonic Mucosa and Reduces Colitis in Mice

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Nanoparticle-based clodronate delivery mitigates murine experimental colitis

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Anatomical, Biochemical and Physiological Considerations of the Colon in Design and Development of Novel Drug Delivery Systems

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Current Drug Delivery (2012)

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Recent Advances in Lipid Nanoparticle Formulations with Solid Matrix for Oral Drug Delivery

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Oral nuclear factor-kappa B decoy oligonucleotides delivery system with chitosan modified poly(D,L-lactide-co-glycolide) nanospheres for inflammatory bowel disease

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Nanoparticle-based Therapeutic Delivery of Prohibitin to the Colonic Epithelial Cells Ameliorates Acute Murine Colitis

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CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice

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Hyaluronan-coated nanoparticles: The influence of the molecular weight on CD44-hyaluronan interactions and on the immune response

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Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated with N-acetyl cysteine

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Enhanced Transferrin Receptor Expression by Proinflammatory Cytokines in Enterocytes as a Means for Local Delivery of Drugs to Inflamed Gut Mucosa

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PAMAM Dendrimers for siRNA Delivery: Computational and Experimental Insights

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Drug delivery using multifunctional dendrimers and hyperbranched polymers

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Orally delivered thioketal nanoparticles loaded with TNF-α-siRNA target inflammation and inhibit gene expression in the intestines

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Anti-oxidant effect of gold nanoparticles restrains hyperglycemic conditions in diabetic mice

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Further Evidence of the Anti-inflammatory Effects of Silver Nanoparticles

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Solid Lipid Nanoparticles: A Modern Formulation Approach in Drug Delivery System

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INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2009)

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Transferrin as a Luminal Target for Negatively Charged Liposomes in the Inflamed Colonic Mucosa

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Lipid Nanoparticles with a Solid Matrix (SLN, NLC, LDC) for Oral Drug Delivery

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DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2008)

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Microbial influences in inflammatory bowel diseases

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Gut instincts: Explorations in intestinal physiology and drug delivery

Emma L. McConnell et al.

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Enhanced oral bioavailability of doxorubicin in a dendrimer drug delivery system

Weilun Ke et al.

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Therapeutic correction of bacterial dysbiosis discovered by molecular techniques

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The gastric emptying of food as measured by gamma-scintigraphy and electrical impedance tomography (EIT) and its influence on the gastric emptying of tablets of different dimensions

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Effects of nanocrystalline silver (NPI 32101) in a rat model of ulcerative colitis

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DIGESTIVE DISEASES AND SCIENCES (2007)

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Prohibitin protects against oxidative stress in intestinal epithelial cells

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Nanoparticles enhance therapeutic efficiency by selectively increased local drug dose in experimental colitis in rats

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Differential adhesion of normal and inflamed rat colonic mucosa by charged liposomes

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Objective evaluation of small bowel and colonic transit time using pH telemetry in athletes with gastrointestinal symptoms

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BRITISH JOURNAL OF SPORTS MEDICINE (2004)

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Challenges for the oral delivery of macromolecules

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Dendrimers conjugates for colonic delivery of 5-aminosalicylic acid

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Antisense oligonucleotide blockade of tumor necrosis factor-alpha in two murine models of colitis

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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)

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The mannose receptor family

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BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2002)

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New cytokine delivery system using gelatin microspheres containing interleukin-10 for experimental inflammatory bowel disease

H Nakase et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)

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Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa

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PHARMACEUTICAL RESEARCH (2001)

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Dermal microvascular endothelial cells express the 180-kDa macrophage mannose receptor in situ and in vitro

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