Journal
JOURNAL OF INTENSIVE CARE MEDICINE
Volume 31, Issue 9, Pages 577-586Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0885066615594344
Keywords
fecal microbiota transplantation; refractory Clostridium difficile infection; recurrent Clostridium difficile colitis; fecal bacteriotherapy; BI; NAP1; 027
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Clostridium difficile infection (CDI) has steadily increased in incidence since the 1990s, with an associated increase in recurrence and severity, which has in turn lead to more intensive care unit (ICU) admissions. The development of recurrent CDI, in particular, has been associated with increasing patient morbidity and mortality as well as an immense financial burden on the health care system. Recently, fecal microbiota transplantation (FMT) has received much publicity as an effective means of treatment for recurrent CDI. The goal of this review is to provide evidence-based recommendations for the diagnosis and management of CDI, with a particular focus on FMT and its utilization in the ICU.
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