Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 65, Pages 9068-9071Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc03118c
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Funding
- National Natural Science Foundation [22022404, 22074050, 82172055, 81870939]
- fundamental research funds for the Central Universities [CCNU22QN007]
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In this study, we synthesized a series of Ru(ii) metallacycles with multimodal chemo-phototherapeutic properties, which showed higher anticancer activity and better cancer-cell selectivity compared to cisplatin. The antitumor mechanism was attributed to the activation of caspase 3/7 and subsequent apoptosis. These findings suggest new potential applications of Ru(ii) metallacycles in biomedicine.
Herein, we construct a series of Ru(ii) metallacycles with multimodal chemo-phototherapeutic properties, which exhibited much higher anticancer activity and better cancer-cell selectivity than cisplatin. The antitumor mechanism could be ascribed to the activation of caspase 3/7 and the resulting apoptosis. These results open new possibilities for Ru(ii) metallacycles in biomedicine.
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