4.2 Article

Prevalence and clinical outcomes of polycythemia vera and essential thrombocythemia with hydroxyurea resistance or intolerance

Journal

HEMATOLOGY
Volume 27, Issue 1, Pages 813-819

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/16078454.2022.2105582

Keywords

Polycythemia vera; essential thrombocythemia; hydroxyurea; hydroxyurea resistance; hydroxyurea intolerance; myeloproliferative neoplasms; splenomegaly

Categories

Ask authors/readers for more resources

This study investigated the prevalence, clinical outcomes, and factors associated with hydroxyurea resistance or intolerance among patients with polycythemia vera and essential thrombocythemia. The study found that patients who had hydroxyurea resistance or intolerance had a significantly increased risk of bleeding events. Low baseline hemoglobin levels, age over 60, and splenomegaly were identified as risk factors for hydroxyurea resistance or intolerance.
Introduction To determine the prevalence, clinical outcomes, and factors associated with hydroxyurea (HU) resistance or intolerance among polycythemia vera (PV) and essential thrombocythemia (ET) patients. Methods This study was a retrospective cohort study including PV and ET patients diagnosed by WHO criteria and treated with HU between January 2000 and June 2020. Clinical features, laboratory data, and resistance or intolerance of HU were collected. The prevalence, clinical outcomes, and associated factors of HU resistance or intolerance were analyzed. Results There were 260 patients including 144 ET and 116 PV. The prevalence of HU resistance or intolerance was 11.9% (31 patients) which was more frequent in ET patients (14.6% vs. 8.6% in PV). Patients who had HU resistance or intolerance significantly increased the risk of bleeding events (HR 2.64; 95% CI 1.19-5.85, P = 0.017). The risk factors of HU resistance or intolerance were low baseline hemoglobin levels (HR 0.90; 95%CI 0.84-0.97, P = 0.01), age more than 60 years old (HR 3.98; 95% CI 2.08-7.62, P < 0.001) and splenomegaly (HR 2.08; 95% CI 1.03-4.21, P = 0.04). Conclusions The prevalence of HU resistance or intolerance in PV and ET patients was 11.9%. Patients with HU resistance or intolerance significantly increased the risk of bleeding complications.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.2
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available