Anncaliia algerae Microsporidiosis Diagnosed by Metagenomic Next-Generation Sequencing, China

We report a case of Anncaliia algerae microsporidia infection in an immunosuppressed kidney transplant recipient in China. Light microscopy and transmission electron microscopy initially failed to identify A. algerae, which eventually was detected by metagenomic nextgeneration sequencing. Our case highlights the supporting role of metagenomic sequencing in early identification of uncommon pathogens.

Automated summary

We present a case of Anncaliia algerae microsporidia infection in an immunosuppressed kidney transplant recipient in China. This pathogen was initially undetectable by light microscopy and transmission electron microscopy, but was eventually identified by metagenomic next-generation sequencing. Our case highlights the critical role of metagenomic sequencing in early identification of uncommon pathogens.