Journal
MEDICINA-LITHUANIA
Volume 58, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/medicina58070900
Keywords
adrenal oncocytic neoplasms; oncocytic adrenal cortical neoplasm with uncertain malignant potential; oncocytic adrenal cortical carcinoma
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Oncocytic adrenal cortical neoplasms, including oncocytoma, oncocytic neoplasms of uncertain malignant potential, and oncocytic adrenal cortical carcinomas, are rare cases. We present a case of oncocytic adrenal cortical carcinoma with scalp metastasis, which is the first reported case of its kind. Our case highlights the limitations of the current diagnostic algorithm and emphasizes the importance of two parameters (PHH3 and Ki-67) in determining the malignant potential of oncocytic adrenal cortical neoplasms.
Oncocytic adrenal cortical neoplasms are rare cases and are divided into oncocytoma, oncocytic neoplasms of uncertain malignant potential and oncocytic adrenal cortical carcinomas, based on the Lin-Weiss-Bisceglia (LWB) histological system adopted in the current World Health Organization (WHO). We reported a 42-year-old female diagnosed with an oncocytic neoplasm of uncertain malignant potential initially, which turned out to be a carcinoma owing to distant metastasis to the scalp and lung. To our knowledge, this is the first published case of oncocytic adrenal cortical carcinoma with scalp metastasis. This case also highlights the limitation of the current diagnostic algorithm and emphasizes the importance of two parameters (PHH3 and Ki-67) for determining the malignant potential of oncocytic adrenal cortical neoplasms.
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