4.8 Review

Mitochondrial dysfunction in cell senescence and aging

Related references

Note: Only part of the references are listed.
Article Geriatrics & Gerontology

Pharmacological Blockade of NLRP3 Inflammasome/IL-1β-Positive Loop Mitigates Endothelial Cell Senescence and Dysfunction

Alejandra Romero et al.

Summary: This study evaluated the role of IL-1β in promoting endothelial senescence and dysfunction through the NLRP3 inflammasome via NF-κB positive feedback. The results showed that the NLRP3 inflammasome played a crucial role in mediating the detrimental effects of IL-1β, and the inhibitor MCC 950 could alleviate inflammation, cell senescence, and vascular dysfunction.

AGING AND DISEASE (2022)

Article Biochemistry & Molecular Biology

Senescence in Post-Mitotic Cells: A Driver of Aging?

Thomas von Zglinicki et al.

Summary: Cell senescence is not limited to proliferating cells, but can also occur in non-dividing cells. Different senescence domains interact with each other and may play a significant role in mammalian aging.

ANTIOXIDANTS & REDOX SIGNALING (2021)

Article Cell Biology

Recent progress in the use of mitochondrial membrane permeability transition pore in mitochondrial dysfunction-related disease therapies

Yuting Cui et al.

Summary: Mitochondrial dysfunction is associated with various diseases, with the abnormal opening of mPTP implicated in the development and pathogenesis of diseases such as IRI, neurodegenerative disorders, tumors, and COPD. The review provides a systematic introduction to the molecular makeup of mPTP and highlights potential underlying mechanisms. Mitigating pore opening through molecules composing mPTP complexes may serve as a potential treatment strategy for mitochondrial dysfunction-related diseases.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Mitochondrial Dysfunction and Mitophagy in Parkinson's Disease: From Mechanism to Therapy

Ana Belen Malpartida et al.

Summary: Mitochondrial dysfunction has long been associated with Parkinson's disease, although its exact role remains unclear. Recent discoveries on the role of PD familial genes in mediating mitophagy and the overlap with sporadic PD have opened up new opportunities for therapeutically targeting mitochondria in PD. Progress has also been made in understanding the upstream and downstream regulators of canonical and noncanonical PINK1/parkin-mediated mitophagy in response to mitochondrial damage.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

Article Cell Biology

NAD+ supplementation prevents STING-induced senescence in ataxia telangiectasia by improving mitophagy

Beimeng Yang et al.

Summary: The study shows that mitochondrial dysfunction and cellular senescence occur in A-T patient fibroblasts, ATM-deficient cells, and mice, and boosting intracellular NAD(+) levels can prevent senescence and senescence-associated secretory phenotype (SASP) by promoting mitophagy in a PINK1-dependent manner. This suggests a central role for mitochondrial dysfunction-induced senescence in A-T pathogenesis and highlights enhancing mitophagy as a potential therapeutic intervention.

AGING CELL (2021)

Article Cell Biology

Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak

Pooja Patel et al.

Summary: The study reveals that inhibiting Bcl-2 family members decreases mitochondrial calcium retention capacity and increases MPTP opening sensitivity. Additionally, inhibition of each Bcl-2 family member exacerbates both apoptotic and necrotic cell death in vitro. Our findings suggest that there is crosstalk between apoptotic and necrotic cell death pathways influenced by Bax/Bak activation/oligomerization on the outer mitochondrial membrane.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Cell Biology

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Ruchi Kumari et al.

Summary: Cellular senescence is a stable cell cycle arrest triggered in response to various stimuli, characterized by dynamic changes in senescent cells. It has both positive effects on tissue repair and anti-cancer mechanisms, but can also negatively impact organismal health. Multiple pathways, including p53/p21 and p16/pRB, play central roles in regulating this process.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

The Role of Mitochondrial Dysfunction in Vascular Disease, Tumorigenesis, and Diabetes

Olga A. Zhunina et al.

Summary: Mitochondrial dysfunction is closely associated with various human pathologies, with ROS and RNS playing a critical role in causing protein and mtDNA damage and leading to the development of diseases. Recent studies have identified numerous mtDNA mutations linked to different human pathologies, each having distinct effects in disease progression.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Article Medicine, Research & Experimental

Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria

Alvaro Gonzalez-Dominguez et al.

Summary: This study showed increased expression of NLRP3 inflammasome components in HGPS skin fibroblasts and lymphoblasts, as well as in hearts and livers of Zmpste24(-/-) mice. Inhibiting the NLRP3 inflammasome with MCC950 improved cellular phenotype, extended lifespan of progeroid animals, and reduced inflammation, suggesting a potential therapeutic approach for HGPS.

EMBO MOLECULAR MEDICINE (2021)

Review Endocrinology & Metabolism

The metabolic roots of senescence: mechanisms and opportunities for intervention

Christopher D. Wiley et al.

Summary: Cellular senescence involves a permanent proliferative arrest and the release of biologically active molecules known as SASP. Studies show that senescence and SASP are sensitive to metabolic states, potentially driving phenotypes associated with metabolic dysfunction. Effective interventions may disrupt the feedback loop in which cellular senescence promotes metabolic diseases.

NATURE METABOLISM (2021)

Review Ophthalmology

Mitophagy: An Emerging Target in Ocular Pathology

Jessica M. Skeie et al.

Summary: This article delves into the importance of mitochondrial function in aerobic eukaryotic cells, emphasizing the balance of mitochondrial dynamics and the mechanism of mitophagy. It also reviews the presence of impaired mitophagy in ocular diseases, offering insight into a potential targeted mechanism for treating ocular diseases characterized by oxidative stress and mitochondrial dysfunction.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2021)

Review Medicine, General & Internal

Senolytic drugs: from discovery to translation

J. L. Kirkland et al.

JOURNAL OF INTERNAL MEDICINE (2020)

Review Cell Biology

Senescence and the SASP: many therapeutic avenues

Jodie Birch et al.

GENES & DEVELOPMENT (2020)

Article Endocrinology & Metabolism

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

Claudia C. S. Chini et al.

NATURE METABOLISM (2020)

Article Endocrinology & Metabolism

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

Anthony J. Covarrubias et al.

NATURE METABOLISM (2020)

Article Biochemistry & Molecular Biology

Cellular Compartmentation and the Redox/Nonredox Functions of NAD+

Chaitanya A. Kulkarni et al.

ANTIOXIDANTS & REDOX SIGNALING (2019)

Article Cell Biology

NAD+ metabolism governs the proinflammatory senescence-associated secretome

Timothy Nacarelli et al.

NATURE CELL BIOLOGY (2019)

Review Medicine, General & Internal

Senolytics and senostatics as adjuvant tumour therapy

Susan Short et al.

EBIOMEDICINE (2019)

Article Biochemistry & Molecular Biology

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline

Claudia Chini et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Cellular Senescence: Defining a Path Forward

Vassilis Gorgoulis et al.

Article Cell Biology

The bystander effect contributes to the accumulation of senescent cells in vivo

Paulo F. L. da Silva et al.

AGING CELL (2019)

Review Cell Biology

Mitochondria and aging: A role for the mitochondrial transition pore?

Mathieu Panel et al.

AGING CELL (2018)

Article Cell Biology

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

Ling Liu et al.

CELL METABOLISM (2018)

Article Cell Biology

The senescent bystander effect is caused by ROS-activated NF-κB signalling

Glyn Nelsons et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2018)

Article Multidisciplinary Sciences

Mechanism of parkin activation by PINK1

Christina Gladkova et al.

NATURE (2018)

Article Multidisciplinary Sciences

&ITS&IT-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy

Salvatore Rizza et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Cell Biology

Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest

Przemyslaw Sapieha et al.

TRENDS IN CELL BIOLOGY (2018)

Review Neurosciences

Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging

Marioly Mueller et al.

FRONTIERS IN NEUROSCIENCE (2018)

Review Biochemistry & Molecular Biology

Cellular Senescence: The Sought or the Unwanted?

Yu Sun et al.

TRENDS IN MOLECULAR MEDICINE (2018)

Review Health Care Sciences & Services

Mitochondrial diseases caused by mtDNA mutations: a mini-review

Anastasia I. Ryzhkova et al.

THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2018)

Article Multidisciplinary Sciences

Cytoplasmic chromatin triggers inflammation in senescence and cancer

Zhixun Dou et al.

NATURE (2017)

Review Geriatrics & Gerontology

Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue

Kerstin Boengler et al.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2017)

Review Medicine, General & Internal

Cellular Senescence: A Translational Perspective

James L. Kirkland et al.

EBIOMEDICINE (2017)

Review Medicine, General & Internal

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

Viktor I. Korolchuk et al.

EBIOMEDICINE (2017)

Article Physiology

Calcium Transport and Signaling in Mitochondria

Roberto Bravo-Sagua et al.

COMPREHENSIVE PHYSIOLOGY (2017)

Article Biochemistry & Molecular Biology

Mitochondrial reactive oxygen species: Do they extend or shorten animal lifespan

Alberto Sanz

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2016)

Review Biochemistry & Molecular Biology

Epigenetic Mechanisms of Longevity and Aging

Payel Sen et al.

Article Cell Biology

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

Christopher D. Wiley et al.

CELL METABOLISM (2016)

Article Biochemistry & Molecular Biology

Mitochondria are required for pro-ageing features of the senescent phenotype

Clara Correia-Melo et al.

EMBO JOURNAL (2016)

Article Biochemistry & Molecular Biology

Mitochondrial stress induces cellular senescence in an mTORC1-dependent manner

Timothy Nacarelli et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Review Biochemistry & Molecular Biology

The Aging Epigenome

Lauren N. Booth et al.

MOLECULAR CELL (2016)

Review Biochemistry & Molecular Biology

The Mitochondrial Basis of Aging

Nuo Sun et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

Autophagy maintains stemness by preventing senescence

Laura Garcia-Prat et al.

NATURE (2016)

Article Multidisciplinary Sciences

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Darren J. Baker et al.

NATURE (2016)

Article Cell Biology

NOTCH1 mediates a switch between two distinct secretomes during senescence

Matthew Hoare et al.

NATURE CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

Erin Quan Toyama et al.

SCIENCE (2016)

Article Biochemistry & Molecular Biology

The role of mitochondrial dysfunction in age-related diseases

Rebecca K. Lane et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2015)

Article Geriatrics & Gerontology

Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?

Timothy Nacarelli et al.

EXPERIMENTAL GERONTOLOGY (2015)

Article Biochemistry & Molecular Biology

Low micromolar concentrations of the superoxide probe MitoSOX uncouple neural mitochondria and inhibit complex IV

Brian A. Roelofs et al.

FREE RADICAL BIOLOGY AND MEDICINE (2015)

Review Endocrinology & Metabolism

SIRT3 regulates progression and development of diseases of aging

Eoin McDonnell et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2015)

Article Cardiac & Cardiovascular Systems

Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5

Min Wan et al.

ATHEROSCLEROSIS (2014)

Article Biochemistry & Molecular Biology

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production

Michael J. White et al.

Review Geriatrics & Gerontology

Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis

Konstantinos Palikaras et al.

EXPERIMENTAL GERONTOLOGY (2014)

Article Biochemistry & Molecular Biology

Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice

Jill E. Kolesar et al.

FREE RADICAL BIOLOGY AND MEDICINE (2014)

Editorial Material Biochemistry & Molecular Biology

Mitohormesis explains ROS-induced health benefits

Michael Ristow

NATURE MEDICINE (2014)

Article Multidisciplinary Sciences

Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice

Satomi Miwa et al.

NATURE COMMUNICATIONS (2014)

Article Multidisciplinary Sciences

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

Ricki J. Colman et al.

NATURE COMMUNICATIONS (2014)

Article Biochemical Research Methods

Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions

Piero Dalle Pezze et al.

PLOS COMPUTATIONAL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways

Jeongsoon Park et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

Peng Jiang et al.

NATURE (2013)

Article Geriatrics & Gerontology

Cytosolic malate dehydrogenase regulates senescence in human fibroblasts

Seung-Min Lee et al.

BIOGERONTOLOGY (2012)

Review Cell Biology

Endoplasmic reticulum-mitochondria contacts: function of the junction

Ashley A. Rowland et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Review Endocrinology & Metabolism

The dynamic regulation of NAD metabolism in mitochondria

Liana Roberts Stein et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2012)

Article Multidisciplinary Sciences

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

Graeme Hewitt et al.

NATURE COMMUNICATIONS (2012)

Article Biochemistry & Molecular Biology

Pathway analysis of NAD+ metabolism

Luis F. de Figueiredo et al.

BIOCHEMICAL JOURNAL (2011)

Review Biochemistry & Molecular Biology

Assessing mitochondrial dysfunction in cells

Martin D. Brand et al.

BIOCHEMICAL JOURNAL (2011)

Review Biochemistry & Molecular Biology

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

Richard C. Scarpulla

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)

Article Multidisciplinary Sciences

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou et al.

NATURE (2011)

Article Multidisciplinary Sciences

Telomere dysfunction induces metabolic and mitochondrial compromise

Erguen Sahin et al.

NATURE (2011)

Article Multidisciplinary Sciences

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker et al.

NATURE (2011)

Article Multidisciplinary Sciences

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

Hyun Tae Kang et al.

PLOS ONE (2011)

Article Cell Biology

Oxidative stress caused by mitochondrial calcium overload

Tsung-I Peng et al.

MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE (2010)

Review Pathology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Jean -Philippe Coppe et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

Review Endocrinology & Metabolism

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

Riekelt H. Houtkooper et al.

ENDOCRINE REVIEWS (2010)

Article Biochemistry & Molecular Biology

Feedback between p21 and reactive oxygen production is necessary for cell senescence

Joao F. Passos et al.

MOLECULAR SYSTEMS BIOLOGY (2010)

Article Cell Biology

Autophagy mediates the mitotic senescence transition

Andrew R. J. Young et al.

GENES & DEVELOPMENT (2009)

Article Biochemistry & Molecular Biology

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

Olga Moiseeva et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Multidisciplinary Sciences

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Carles Canto et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition

Magnus J. Hansson et al.

FREE RADICAL BIOLOGY AND MEDICINE (2008)

Article Genetics & Heredity

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

Marc Vermulst et al.

NATURE GENETICS (2008)

Article Biochemistry & Molecular Biology

Mammalian sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

David B. Lombard et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Biotechnology & Applied Microbiology

Mitochondria as determinant of nucleotide pools and chromosomal stability

Claus Desler et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2007)

Article Biochemistry & Molecular Biology

Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence

Seungmin Lee et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

Joao F. Passos et al.

PLOS BIOLOGY (2007)

Article Multidisciplinary Sciences

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

Raffaella Di Micco et al.

NATURE (2006)

Article Multidisciplinary Sciences

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

A Trifunovic et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

GC Kujoth et al.

SCIENCE (2005)

Review Genetics & Heredity

Mitochondrial DNA mutations in human disease

RW Taylor et al.

NATURE REVIEWS GENETICS (2005)

Article Biochemistry & Molecular Biology

Cellular aging of mitochondrial DNA-depleted cells

SY Park et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Article Geriatrics & Gerontology

Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease

DK Simon et al.

NEUROBIOLOGY OF AGING (2004)

Article Biochemistry & Molecular Biology

Cardiolipin induces premature senescence in normal human fibroblasts

P Arivazhagan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Review Cell Biology

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

PS Brookes et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)

Article Multidisciplinary Sciences

A DNA damage checkpoint response in telomere-initiated senescence

FD di Fagagna et al.

NATURE (2003)

Article Biochemistry & Molecular Biology

Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence

S Macip et al.

EMBO JOURNAL (2002)