Related references
Note: Only part of the references are listed.Pharmacological Blockade of NLRP3 Inflammasome/IL-1β-Positive Loop Mitigates Endothelial Cell Senescence and Dysfunction
Alejandra Romero et al.
AGING AND DISEASE (2022)
Senescence in Post-Mitotic Cells: A Driver of Aging?
Thomas von Zglinicki et al.
ANTIOXIDANTS & REDOX SIGNALING (2021)
Recent progress in the use of mitochondrial membrane permeability transition pore in mitochondrial dysfunction-related disease therapies
Yuting Cui et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)
Mitochondrial Dysfunction and Mitophagy in Parkinson's Disease: From Mechanism to Therapy
Ana Belen Malpartida et al.
TRENDS IN BIOCHEMICAL SCIENCES (2021)
NAD+ supplementation prevents STING-induced senescence in ataxia telangiectasia by improving mitophagy
Beimeng Yang et al.
AGING CELL (2021)
Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak
Pooja Patel et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Ruchi Kumari et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)
The Role of Mitochondrial Dysfunction in Vascular Disease, Tumorigenesis, and Diabetes
Olga A. Zhunina et al.
FRONTIERS IN MOLECULAR BIOSCIENCES (2021)
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson-Gilford Progeria
Alvaro Gonzalez-Dominguez et al.
EMBO MOLECULAR MEDICINE (2021)
The metabolic roots of senescence: mechanisms and opportunities for intervention
Christopher D. Wiley et al.
NATURE METABOLISM (2021)
Mitophagy: An Emerging Target in Ocular Pathology
Jessica M. Skeie et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2021)
Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
Maria Grazia Vizioli et al.
GENES & DEVELOPMENT (2020)
Senolytic drugs: from discovery to translation
J. L. Kirkland et al.
JOURNAL OF INTERNAL MEDICINE (2020)
Senescence and the SASP: many therapeutic avenues
Jodie Birch et al.
GENES & DEVELOPMENT (2020)
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels
Claudia C. S. Chini et al.
NATURE METABOLISM (2020)
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages
Anthony J. Covarrubias et al.
NATURE METABOLISM (2020)
Cellular Compartmentation and the Redox/Nonredox Functions of NAD+
Chaitanya A. Kulkarni et al.
ANTIOXIDANTS & REDOX SIGNALING (2019)
NAD+ metabolism governs the proinflammatory senescence-associated secretome
Timothy Nacarelli et al.
NATURE CELL BIOLOGY (2019)
Senolytics and senostatics as adjuvant tumour therapy
Susan Short et al.
EBIOMEDICINE (2019)
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline
Claudia Chini et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
Cellular Senescence: Defining a Path Forward
Vassilis Gorgoulis et al.
CELL (2019)
The bystander effect contributes to the accumulation of senescent cells in vivo
Paulo F. L. da Silva et al.
AGING CELL (2019)
The relevance of the supramolecular arrangements of the respiratory chain complexes in human diseases and aging
Ixchel Ramirez-Camacho et al.
MITOCHONDRION (2019)
Mitochondria and aging: A role for the mitochondrial transition pore?
Mathieu Panel et al.
AGING CELL (2018)
Mitochondrial peptides modulate mitochondrial function during cellular senescence
Su-Jeong Kim et al.
AGING-US (2018)
Quantitative Analysis of NAD Synthesis-Breakdown Fluxes
Ling Liu et al.
CELL METABOLISM (2018)
The senescent bystander effect is caused by ROS-activated NF-κB signalling
Glyn Nelsons et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2018)
Mechanism of parkin activation by PINK1
Christina Gladkova et al.
NATURE (2018)
&ITS&IT-nitrosylation drives cell senescence and aging in mammals by controlling mitochondrial dynamics and mitophagy
Salvatore Rizza et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest
Przemyslaw Sapieha et al.
TRENDS IN CELL BIOLOGY (2018)
IP3R-Grp75-VDAC1-MCU calcium regulation axis antagonists protect podocytes from apoptosis and decrease proteinuria in an Adriamycin nephropathy rat model
Han Xu et al.
BMC NEPHROLOGY (2018)
Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging
Marioly Mueller et al.
FRONTIERS IN NEUROSCIENCE (2018)
Cellular Senescence: The Sought or the Unwanted?
Yu Sun et al.
TRENDS IN MOLECULAR MEDICINE (2018)
Interaction of mitochondria fission factor with dynamin related protein 1 governs physiological mitochondria function in vivo
Opher S. Kornfeld et al.
SCIENTIFIC REPORTS (2018)
Mitochondrial diseases caused by mtDNA mutations: a mini-review
Anastasia I. Ryzhkova et al.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2018)
Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway
Yanlin Yin et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2017)
Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing
Bernadette Carroll et al.
JOURNAL OF CELL BIOLOGY (2017)
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Zhixun Dou et al.
NATURE (2017)
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
Selene Gluck et al.
NATURE CELL BIOLOGY (2017)
Senoptosis: non-lethal DNA cleavage as a route to deep senescence
Maja Studencka et al.
Oncotarget (2017)
Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue
Kerstin Boengler et al.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2017)
Cellular Senescence: A Translational Perspective
James L. Kirkland et al.
EBIOMEDICINE (2017)
Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?
Viktor I. Korolchuk et al.
EBIOMEDICINE (2017)
The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore
Hagai Rottenberg et al.
AGING CELL (2017)
Calcium Transport and Signaling in Mitochondria
Roberto Bravo-Sagua et al.
COMPREHENSIVE PHYSIOLOGY (2017)
New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463
Yi Zhu et al.
AGING-US (2017)
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
Yi Zhu et al.
AGING CELL (2016)
Mitochondrial reactive oxygen species: Do they extend or shorten animal lifespan
Alberto Sanz
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2016)
Epigenetic Mechanisms of Longevity and Aging
Payel Sen et al.
CELL (2016)
Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization
Wen Yang et al.
CELL (2016)
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism
Juliana Camacho-Pereira et al.
CELL METABOLISM (2016)
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
Christopher D. Wiley et al.
CELL METABOLISM (2016)
Mitochondria are required for pro-ageing features of the senescent phenotype
Clara Correia-Melo et al.
EMBO JOURNAL (2016)
Mitochondrial stress induces cellular senescence in an mTORC1-dependent manner
Timothy Nacarelli et al.
FREE RADICAL BIOLOGY AND MEDICINE (2016)
The Aging Epigenome
Lauren N. Booth et al.
MOLECULAR CELL (2016)
The Mitochondrial Basis of Aging
Nuo Sun et al.
MOLECULAR CELL (2016)
Autophagy maintains stemness by preventing senescence
Laura Garcia-Prat et al.
NATURE (2016)
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Darren J. Baker et al.
NATURE (2016)
NOTCH1 mediates a switch between two distinct secretomes during senescence
Matthew Hoare et al.
NATURE CELL BIOLOGY (2016)
AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
Erin Quan Toyama et al.
SCIENCE (2016)
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Yi Zhu et al.
AGING CELL (2015)
The role of mitochondrial dysfunction in age-related diseases
Rebecca K. Lane et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2015)
Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?
Timothy Nacarelli et al.
EXPERIMENTAL GERONTOLOGY (2015)
Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease
Tanveer Ahmad et al.
FASEB JOURNAL (2015)
Low micromolar concentrations of the superoxide probe MitoSOX uncouple neural mitochondria and inhibit complex IV
Brian A. Roelofs et al.
FREE RADICAL BIOLOGY AND MEDICINE (2015)
Regulation of mitochondrial biogenesis through TFAM-mitochondrial DNA interactions Useful insights from aging and calorie restriction studies
Anna Picca et al.
MITOCHONDRION (2015)
Limited Mitochondrial Permeabilization Causes DNA Damage and Genomic Instability in the Absence of Cell Death
Gabriel Ichim et al.
MOLECULAR CELL (2015)
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4
Chanhee Kang et al.
SCIENCE (2015)
SIRT3 regulates progression and development of diseases of aging
Eoin McDonnell et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2015)
Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5
Min Wan et al.
ATHEROSCLEROSIS (2014)
Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
Michael J. White et al.
CELL (2014)
Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for inflamm- aging
Marcello Pinti et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2014)
Mitochondrial homeostasis: The interplay between mitophagy and mitochondrial biogenesis
Konstantinos Palikaras et al.
EXPERIMENTAL GERONTOLOGY (2014)
Defects in mitochondrial DNA replication and oxidative damage in muscle of mtDNA mutator mice
Jill E. Kolesar et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
Mitohormesis explains ROS-induced health benefits
Michael Ristow
NATURE MEDICINE (2014)
Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence
Clotilde Wiel et al.
NATURE COMMUNICATIONS (2014)
Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice
Satomi Miwa et al.
NATURE COMMUNICATIONS (2014)
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
Ricki J. Colman et al.
NATURE COMMUNICATIONS (2014)
Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions
Piero Dalle Pezze et al.
PLOS COMPUTATIONAL BIOLOGY (2014)
Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing
Laura C. Greaves et al.
PLOS GENETICS (2014)
Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-B activation
Olga Moiseeva et al.
AGING CELL (2013)
SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism
Seung Min Jeong et al.
CANCER CELL (2013)
Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Yun-Hee Youm et al.
CELL METABOLISM (2013)
SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways
Jeongsoon Park et al.
MOLECULAR CELL (2013)
Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
Peng Jiang et al.
NATURE (2013)
AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
Antero Salminen et al.
AGEING RESEARCH REVIEWS (2012)
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response
Diana Jurk et al.
AGING CELL (2012)
Cytosolic malate dehydrogenase regulates senescence in human fibroblasts
Seung-Min Lee et al.
BIOGERONTOLOGY (2012)
Endoplasmic reticulum-mitochondria contacts: function of the junction
Ashley A. Rowland et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
The dynamic regulation of NAD metabolism in mitochondria
Liana Roberts Stein et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2012)
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence
Graeme Hewitt et al.
NATURE COMMUNICATIONS (2012)
Pathway analysis of NAD+ metabolism
Luis F. de Figueiredo et al.
BIOCHEMICAL JOURNAL (2011)
Assessing mitochondrial dysfunction in cells
Martin D. Brand et al.
BIOCHEMICAL JOURNAL (2011)
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
Richard C. Scarpulla
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2011)
AMP-activated protein kinase-an energy sensor that regulates all aspects of cell function
D. Grahame Hardie
GENES & DEVELOPMENT (2011)
A role for mitochondria in NLRP3 inflammasome activation
Rongbin Zhou et al.
NATURE (2011)
Telomere dysfunction induces metabolic and mitochondrial compromise
Erguen Sahin et al.
NATURE (2011)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Darren J. Baker et al.
NATURE (2011)
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
Kiichi Nakahira et al.
NATURE IMMUNOLOGY (2011)
Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts
Hyun Tae Kang et al.
PLOS ONE (2011)
Oxidative stress caused by mitochondrial calcium overload
Tsung-I Peng et al.
MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE (2010)
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
Jean -Philippe Coppe et al.
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)
Calorie restriction Decelerating mTOR-driven aging from cells to organisms (including humans)
Mikhail V. Blagosklonny
CELL CYCLE (2010)
The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways
Riekelt H. Houtkooper et al.
ENDOCRINE REVIEWS (2010)
Feedback between p21 and reactive oxygen production is necessary for cell senescence
Joao F. Passos et al.
MOLECULAR SYSTEMS BIOLOGY (2010)
Autophagy mediates the mitotic senescence transition
Andrew R. J. Young et al.
GENES & DEVELOPMENT (2009)
The Relationship between the Aging- and Photo-Dependent T414G Mitochondrial DNA Mutation with Cellular Senescence and Reactive Oxygen Species Production in Cultured Skin Fibroblasts
Matthew J. Birket et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)
Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence
Olga Moiseeva et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Carles Canto et al.
NATURE (2009)
Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated by permeability transition
Magnus J. Hansson et al.
FREE RADICAL BIOLOGY AND MEDICINE (2008)
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice
Marc Vermulst et al.
NATURE GENETICS (2008)
Mammalian sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
David B. Lombard et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Mitochondria as determinant of nucleotide pools and chromosomal stability
Claus Desler et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2007)
Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence
Seungmin Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
Joao F. Passos et al.
PLOS BIOLOGY (2007)
Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
Raffaella Di Micco et al.
NATURE (2006)
Formation of elongated giant mitochondria in DFO-induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1
Young-Sil Yoon et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production
A Trifunovic et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
GC Kujoth et al.
SCIENCE (2005)
Mitochondrial DNA mutations in human disease
RW Taylor et al.
NATURE REVIEWS GENETICS (2005)
TGF β1 induces prolonged mitochondrial ROS generation through decreased complex IV activity with senescent arrest in Mv1Lu cells
YS Yoon et al.
ONCOGENE (2005)
Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition
CC Alano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Cellular aging of mitochondrial DNA-depleted cells
SY Park et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease
DK Simon et al.
NEUROBIOLOGY OF AGING (2004)
Cardiolipin induces premature senescence in normal human fibroblasts
P Arivazhagan et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Calcium, ATP, and ROS: a mitochondrial love-hate triangle
PS Brookes et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)
A DNA damage checkpoint response in telomere-initiated senescence
FD di Fagagna et al.
NATURE (2003)
Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines:: association of transforming growth factor β1 (TGF-β1)-mediated p27Kip1 expression
G Yoon et al.
BIOCHEMICAL JOURNAL (2002)
Inhibition of p21-mediated ROS accumulation can rescue p21-induced senescence
S Macip et al.
EMBO JOURNAL (2002)
Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence
HC Lee et al.
JOURNAL OF BIOMEDICAL SCIENCE (2002)