Journal
CURRENT ISSUES IN MOLECULAR BIOLOGY
Volume 44, Issue 7, Pages 3156-3165Publisher
MDPI
DOI: 10.3390/cimb44070218
Keywords
mitochondrial dysfunction; drug-induced liver injury; alcoholic fatty liver; non-alcoholic fatty liver; hepatocellular carcinoma; viral hepatitis
Categories
Funding
- Natural Science Foundation of China [32000125]
- National Fostering Science Fund Project of Henan Normal University [20A180014]
- Doctoral Research Foundation of Henan Normal University [5101049170192]
- Scientific and Technological Breakthroughs Project of Henan [222102310291, 222102310589]
- Higher Education Research Key Project of Henan [22A180018, 21A180009]
Ask authors/readers for more resources
Mitochondria, the powerhouse of the cell, not only produce cellular energy but also play a role in various biological functions. Dysfunction in mitochondria is associated with the occurrence and development of chronic liver diseases.
Mitochondria are generally considered the powerhouse of the cell, a small subcellular organelle that produces most of the cellular energy in the form of adenosine triphosphate (ATP). In addition, mitochondria are involved in various biological functions, such as biosynthesis, lipid metabolism, oxidative phosphorylation, cell signal transduction, and apoptosis. Mitochondrial dysfunction is manifested in different aspects, like increased mitochondrial reactive oxygen species (ROS), mitochondrial DNA (mtDNA) damage, adenosine triphosphate (ATP) synthesis disorder, abnormal mitophagy, as well as changes in mitochondrial morphology and structure. Mitochondrial dysfunction is related to the occurrence and development of various chronic liver diseases, including hepatocellular carcinoma (HCC), viral hepatitis, drug-induced liver injury (DILI), alcoholic fatty liver (AFL), and non-alcoholic fatty liver (NAFL). In this review, we summarize and discuss the role and mechanisms of mitochondrial dysfunction in chronic liver disease, focusing on and discussing some of the latest studies on mitochondria and chronic liver disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available