Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 18, Issue 6, Pages 2472-2483Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.69458
Keywords
A-to-I RNA editing; Cancer; Interactive analysis; Multi-omics; Database
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Funding
- National Key Research and Development Program of China [2017YFA0102801]
- National Natural Science Foundation of China (NSFC) [61501127, 31871323, 31930058]
- Guangdong Basic and Applied Basic Research Foundation [2020A151 5010526]
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This paper presents REIA, an interactive web server for analyzing and visualizing the association between human cancers and A-to-I RNA editing sites. REIA offers various options to browse annotation/editing levels and compare differences between editing and non-editing groups.
Epitranscriptomic changes caused by adenosine-to-inosine (A-to-I) RNA editing contribute to the pathogenesis of human cancers; however, only a small fraction of the millions editing sites detected so far has clear functionality. To facilitate more in-depth studies on the editing, this paper offers REIA (http://bioinfo-sysu.com/reia), an interactive web server that analyses and visualizes the association between human cancers and A-to-I RNA editing sites (RESs). As a comprehensive database, REIA curates not only 8,447,588 RESs from 9,895 patients across 34 cancers, where 33 are from TCGA and 1 from GEO, but also 13 different types of multi-omic data for the cancers. As an interactive server, REIA provides various options for the user to specify the interested sites, to browse their annotation/editing level/profile in cancer, and to compare the difference in multi-omic features between editing and non-editing groups. From the editing profiles, REIA further detects 658 peptides that are supported by mass spectrum data but not yet covered in any prior works.
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