3.8 Article

Mitochondria in neurodegeneration

Related references

Note: Only part of the references are listed.
Review Cell Biology

Regulation of PRKN-independent mitophagy

Petra Teresak et al.

Summary: Mitochondria are essential for cellular homeostasis, with mitophagy being a prominent mechanism to maintain a healthy mitochondrial pool. While the PINK1-PRKN pathway is well-studied for mitophagy, there are also alternative pathways involving different proteins and lipids. The significance of PRKN-independent mitophagy pathways in various physiological and pathophysiological processes highlights the need for further research into their regulation and interactions.

AUTOPHAGY (2022)

Article Biochemistry & Molecular Biology

Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex

Shafqat Rasool et al.

Summary: Mutations in PINK1 lead to Parkinson's disease. The study shows that PINK1 is imported into the translocase of the outer mitochondrial membrane (TOM) complex, leading to its activation by autophosphorylation and initiation of mitochondrial clearance. The crystal structures provide insights into the dimeric autophosphorylation complex and the stabilization mechanism of PINK1 on the core TOM complex.

MOLECULAR CELL (2022)

Article Clinical Neurology

Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment

Javier Jarazo et al.

Summary: This study investigated the differences between neurons derived from Parkinson's disease patients and controls, identifying potential pathways for targeted treatment. By correcting mutations and using a specific compound, improvements in metabolic properties and neuronal differentiation in patient-derived cells were observed. Treatment with a repurposed compound was shown to restore impaired dopaminergic differentiation in Parkinson's disease patient-derived cells.

MOVEMENT DISORDERS (2022)

Article Multidisciplinary Sciences

Activation mechanism of PINK1

Zhong Yan Gan et al.

Summary: The research on the activation mechanism of PINK1 using crystallography and cryo-electron microscopy revealed the orientation of unphosphorylated yet active PINK1 on mitochondria, conformational changes to an active ubiquitin kinase state, and the role of regulatory PINK1 oxidation. The study also elucidates how PINK1 interacts with the mitochondrial outer membrane and suggests that PINK1 activity may be modulated by mitochondrial reactive oxygen species.

NATURE (2022)

Article Cell Biology

Serine protease HtrA2/Omi regulates adaptive mitochondrial reprogramming in the brain cortex after ischemia/reperfusion injury via UCP2-SIRT3-PGC1 axis

Hao Meng et al.

Summary: This study investigates the role of HtrA2/Omi in mitochondrial quality control during ischemia/reperfusion injury. Heterozygous mice with increased HtrA2/Omi expression show improved mitochondrial function and reduced neurodegeneration compared to wild-type mice. The findings suggest that modulation of the UCP2-SIRT3-PGC1 axis may provide neuroprotection against brain ischemia/reperfusion injury.

HUMAN CELL (2022)

Article Cell Biology

VCP/p97 cofactor UBXN1/SAKS1 regulates mitophagy by modulating MFN2 removal from mitochondria

Chantal Mengus et al.

Summary: The VCP cofactor UBXN1 plays a crucial role in the initiation and maintenance of PINK1- and PRKN-dependent mitophagy, by facilitating MFN2 removal and regulating PRKN translocation to depolarized mitochondria.

AUTOPHAGY (2022)

Article Cell Biology

Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease

Sandra Franco-Iborra et al.

Summary: The study found that HTT protein plays a crucial role in mitophagy, and the expansion of its polyQ tract affects this process, ultimately leading to the accumulation of damaged mitochondria and an increase in oxidative stress, leading to negative effects on mitochondrial dysfunction and neurodegeneration in Huntington disease.

AUTOPHAGY (2021)

Article Cell Biology

Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain

Shefali Krishna et al.

Summary: Research has found that mitochondria in the mouse brain can be long-lived, with specific mitochondrial proteins having half-lives longer than the average proteome. These long-lived mitochondrial proteins are core components of the electron transport chain, and their extended longevity contributes to the maintenance of respiratory supercomplexes.

DEVELOPMENTAL CELL (2021)

Article Biochemistry & Molecular Biology

TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS

Xinxin Zuo et al.

Summary: Initially thought to be associated with oxidative stress, ALS is now understood to involve genes related to RNA processing and proteostasis, leading to the convergence of different biological pathways causing the disease. Aggregation of TDP-43 in neurons increases sensitivity to oxidative stress and dysregulates specific miRNAs and proteins, impacting mitochondrial function and promoting ALS initiation and progression.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

Article Neurosciences

Dendritic Architecture Predicts in vivo Firing Pattern in Mouse Ventral Tegmental Area and Substantia Nigra Dopaminergic Neurons

Trinidad Montero et al.

Summary: The firing activity and dendritic morphology of VTA and SNc dopaminergic neurons were studied in adult male mice. The results showed that VTA neurons with shorter and simpler dendritic architecture exhibited more irregular firing, while SNc neurons with smaller dendritic domains had higher firing irregularity. Differences in dendritic morphology contribute to the in vivo firing properties of individual DA neurons, suggesting region-specific synaptic connectivity rules that shape firing diversity.

FRONTIERS IN NEURAL CIRCUITS (2021)

Article Physiology

Pharmacological inhibition of USP30 activates tissue-specific mitophagy

Hongke Luo et al.

Summary: Mitophagy is a regulated process that targets damaged mitochondria for removal. Inhibiting the mitochondrial deubiquitinase USP30 can increase mitophagic flux, offering potential for novel therapeutic approaches.

ACTA PHYSIOLOGICA (2021)

Article Multidisciplinary Sciences

Distinct fission signatures predict mitochondrial degradation or biogenesis

Tatjana Kleele et al.

Summary: Mitochondrial fission is a highly regulated process that can impact cell function and health. Depending on the location and manner of division, mitochondria can be divided into two types, one for clearing damaged material and undergoing mitophagy, and the other for mitochondrial proliferation.

NATURE (2021)

Article Multidisciplinary Sciences

PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons

Sarah J. Brown et al.

Summary: Recent evidence suggests that neurogenesis continues throughout life but the impact on neurodegenerative disorders like Parkinson's disease is still unclear. Studies in zebrafish and human organoids show that PINK1 deficiency impairs adult dopaminergic neurogenesis, potentially affecting future therapeutic approaches for PD patients with biallelic PINK1 mutations.

SCIENTIFIC REPORTS (2021)

Review Biochemistry & Molecular Biology

Dysregulation of Astrocyte Ion Homeostasis and Its Relevance for Stroke-Induced Brain Damage

Michel J. A. M. van Putten et al.

Summary: Ischemic stroke is a major cause of mortality and chronic disability, with astrocytes playing a central role in the dynamics of recovery or progression of stroke-induced brain damage. Dysfunction of astrocytes can lead to issues such as maintenance of cellular volume and cerebral edema under ischemic conditions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Long-lived mitochondrial cristae proteins in mouse heart and brain

Ewa Bomba-Warczak et al.

Summary: Long-lived proteins in mitochondria, known as mt-LLPs, can persist for months in tissues with long-lived cells like brain and heart. They are enriched in the inner mitochondrial membrane, specifically in the cristae subcompartment, providing key structural stability to intracellular structures. Pioneering cross-linking experiments revealed limited subunit exchange within protein OXPHOS complexes throughout the lifetimes of mt-LLPs.

JOURNAL OF CELL BIOLOGY (2021)

Article Neurosciences

Cleaved PINK1 induces neuronal plasticity through PKA-mediated BDNF functional regulation

Smijin K. Soman et al.

Summary: Research shows that cPINK1 supports neuronal development by modulating the expression and release of BDNF, activating the PKA-CREB-BDNF signaling axis. cPINK1 plays a crucial role in neurons, but further studies are needed to understand its molecular mechanisms.

JOURNAL OF NEUROSCIENCE RESEARCH (2021)

Article Multidisciplinary Sciences

ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy

Olivia Harding et al.

Summary: TBK1, a multifunctional kinase, plays a crucial role in mitophagy and its mutations associated with ALS may contribute to disease pathogenesis by inducing mitochondrial stress or inhibiting mitophagic flux. Some TBK1 mutations have minimal impact on mitophagy, suggesting that cell-type specific effects, cumulative damage, or other TBK1-dependent pathways also play a role in the development of ALS.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Review Medicine, General & Internal

Mitochondrial disease in children

S. Rahman

JOURNAL OF INTERNAL MEDICINE (2020)

Article Multidisciplinary Sciences

Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease

Maria Calvo-Rodriguez et al.

NATURE COMMUNICATIONS (2020)

Article Cell Biology

Drosophila VCP/p97 Mediates Dynein-Dependent Retrograde Mitochondrial Motility in Axons

Ashley E. Gonzalez et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Mitochondrial protein biogenesis in the synapse is supported by local translation

Bozena Kuzniewska et al.

EMBO REPORTS (2020)

Article Biochemistry & Molecular Biology

Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss

Margrethe A. Olesen et al.

REDOX BIOLOGY (2020)

Review Neurosciences

Autophagy and mitophagy in ALS

Chantell S. Evans et al.

NEUROBIOLOGY OF DISEASE (2019)

Article Neurosciences

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation

Cristina Guardia-Laguarta et al.

JOURNAL OF NEUROSCIENCE (2019)

Article Cell Biology

Overexpression of Mitochondrial Calcium Uniporter Causes Neuronal Death

Veronica Granatiero et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Article Multidisciplinary Sciences

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease

Pooja Jadiya et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Spatially Stable Mitochondrial Compartments Fuel Local Translation during Plasticity

Vidhya Rangaraju et al.

Article Nutrition & Dietetics

CKD autophagy activation and skeletal muscle atrophy-a preliminary study of mitophagy and inflammation

Yue Yue Zhang et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2019)

Article Multidisciplinary Sciences

Mitochondria modulate programmed neuritic retraction

Sergei V. Baranov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Cell Biology

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

Thomas G. McWilliams et al.

CELL METABOLISM (2018)

Article Biochemistry & Molecular Biology

Dual role of USP30 in controlling basal pexophagy and mitophagy

Elena Marcassa et al.

EMBO REPORTS (2018)

Article Biochemistry & Molecular Biology

PINK1 autophosphorylation is required for ubiquitin recognition

Shafqat Rasool et al.

EMBO REPORTS (2018)

Article Cell Biology

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin

Juliette J. Lee et al.

JOURNAL OF CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response

Olga Zurita Rendon et al.

MOLECULAR AND CELLULAR BIOLOGY (2018)

Article Multidisciplinary Sciences

Parkin and PINK1 mitigate STING-induced inflammation

Danielle A. Sliter et al.

NATURE (2018)

Article Biochemistry & Molecular Biology

PINK1 regulates mitochodrial trafficking in dentrites of cortical neurons therough mitochondrial PKA

Tania Das Banerjee et al.

JOURNAL OF NEUROCHEMISTRY (2017)

Article Multidisciplinary Sciences

Structure of PINK1 in complex with its substrate ubiquitin

Alexander F. Schubert et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease

Adam L. Orr et al.

NEUROCHEMISTRY INTERNATIONAL (2017)

Article Environmental Sciences

Dendritic Architecture of Principal Basolateral Amygdala Neurons Changes Congruently with Endocrine Response to Stress

Akshaya Hegde et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2017)

Article Multidisciplinary Sciences

Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson's disease

Brianada Koentjoro et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy

V. E. Kagan et al.

CELL DEATH AND DIFFERENTIATION (2016)

Article Biochemistry & Molecular Biology

Drosophila clueless is involved in Parkin-dependent mitophagy by promoting VCP-mediated Marf degradation

Zong-Heng Wang et al.

HUMAN MOLECULAR GENETICS (2016)

Article Biochemistry & Molecular Biology

Shuttling of PINK1 between Mitochondrial Microcompartments Resolved by Triple-Color Superresolution Microscopy

Felix R. M. Beinlich et al.

ACS CHEMICAL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Selective dendritic susceptibility to bioenergetic, excitotoxic and redox perturbations in cortical neurons

Philip Hasel et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)

Article Biochemistry & Molecular Biology

ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells

Natalie Al-Furoukh et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)

Article Biochemistry & Molecular Biology

Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains

Xuan Ye et al.

HUMAN MOLECULAR GENETICS (2015)

Article Biochemistry & Molecular Biology

BAG2 Gene-mediated Regulation of PINK1 Protein Is Critical for Mitochondrial Translocation of PARKIN and Neuronal Survival

Dianbo Qu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemical Research Methods

Synaptic mitochondria: A brain mitochondria cluster with a specific proteome

Katalin Voelgyi et al.

JOURNAL OF PROTEOMICS (2015)

Article Biochemistry & Molecular Biology

Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration

Edward D. Plowey et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Article Biochemistry & Molecular Biology

Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

Vidhya Rangaraju et al.

Article Biochemistry & Molecular Biology

Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through Protein Kinase A

Ruben K. Dagda et al.

JOURNAL OF NEUROCHEMISTRY (2014)

Article Multidisciplinary Sciences

Transcellular degradation of axonal mitochondria

Chung-ha O. Davis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Pathology

Mutant LRRK2 Elicits Calcium Imbalance and Depletion of Dendritic Mitochondria in Neurons

Salvatore J. Cherra et al.

AMERICAN JOURNAL OF PATHOLOGY (2013)

Article Biochemistry & Molecular Biology

Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport

Diana Zala et al.

Article Biochemistry & Molecular Biology

A Neo-Substrate that Amplifies Catalytic Activity of Parkinson's-Disease-Related Kinase PINK1

Nicholas T. Hertz et al.

Article Biochemistry & Molecular Biology

TRAP1 rescues PINK1 loss-of-function phenotypes

Li Zhang et al.

HUMAN MOLECULAR GENETICS (2013)

Article Endocrinology & Metabolism

Mitochondrial calcium uptake capacity modulates neocortical excitability

Basavaraju G. Sanganahalli et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2013)

Article Multidisciplinary Sciences

The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo

Evelyn S. Vincow et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Clinical Neurology

F-Box Only Protein 7 Gene in Parkinsonian-Pyramidal Disease

Hao Deng et al.

JAMA NEUROLOGY (2013)

Article Biochemistry & Molecular Biology

PINK1 stimulates interleukin-1β-mediated inflammatory signaling via the positive regulation of TRAF6 and TAK1

Hyun Jung Lee et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

Review Biochemistry & Molecular Biology

Mitochondrial respiratory chain dysfunction: Implications in neurodegeneration

Maria Moran et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Biochemistry & Molecular Biology

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

Xinglong Wang et al.

HUMAN MOLECULAR GENETICS (2012)

Article Biochemistry & Molecular Biology

A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1 ACTIVATION OF AKT VIA MTORC2

Hitoshi Murata et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Medicine, Research & Experimental

Valosin-containing protein and neurofibromin interact to regulate dendritic spine density

Hsiao-Fang Wang et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Neurosciences

Akt Suppresses Retrograde Degeneration of Dopaminergic Axons by Inhibition of Macroautophagy

Hsiao-Chun Cheng et al.

JOURNAL OF NEUROSCIENCE (2011)

Article Multidisciplinary Sciences

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

Fredrik H. Sterky et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Biochemistry & Molecular Biology

PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy

Sumihiro Kawajiri et al.

FEBS LETTERS (2010)

Article Biochemistry & Molecular Biology

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Derek P. Narendra et al.

PLOS BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

Ruben K. Dagda et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-induced Cell Death

Sonia Gandhi et al.

MOLECULAR CELL (2009)

Article Cell Biology

Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin

Alexander J. Whitworth et al.

DISEASE MODELS & MECHANISMS (2008)

Article Cell Biology

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Derek Narendra et al.

JOURNAL OF CELL BIOLOGY (2008)

Article Multidisciplinary Sciences

The PINK1/Parkin pathway regulates mitochondrial morphology

Angela C. Poole et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Neurosciences

Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons

Yi Yang et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2007)

Article Cell Biology

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1

Helene Plun-Favreau et al.

NATURE CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

Julia W. Pridgeon et al.

PLOS BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Synaptic mitochondria are more susceptible to Ca2+ overload than nonsynaptic mitochondria

MR Brown et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Clinical Neurology

Novel PINK1 mutations in early-onset parkinsonism

Y Hatano et al.

ANNALS OF NEUROLOGY (2004)

Article Multidisciplinary Sciences

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

EM Valente et al.

SCIENCE (2004)

Article Neurosciences

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

R Betarbet et al.

NATURE NEUROSCIENCE (2000)