Dimensionality reduction boosts the peroxidase-like activity of bimetallic MOFs for enhanced multidrug-resistant bacteria eradication

The antibacterial strategy using cutting-edge metal-organic framework (MOF)-based nanozymes can effectively solve the problem caused by antibiotic resistance to protect human health and the environment; however it has been significantly limited by the complicated modification method and non-ideal catalytic activity. Herein, we report a facile dimensionality-reduction strategy to improve the catalytic activity of MOF-based nanozymes. By reducing the dimensionality of two-dimensional Co-TCPP(Fe) (Co-Fe NSs) to zero-dimensional Co-TCPP(Fe) (Co-Fe NDs), the peroxidase-like activity of the prepared bimetallic Co-Fe NDs was almost tripled. Consequently, the bimetallic Co-Fe NDs can highly efficiently catalyze the lower-concentration H2O2 into reactive oxygen species (ROS), resulting in a favorable antibacterial effect against methicillin-resistant Staphylococcus aureus (MRSA). Meanwhile, Co-Fe NDs can effectively promote wound healing and water environment disinfection with good biocompatibility. This work reveals the potential of a zero-dimensional bimetallic MOF-based nanozyme in resisting drug-resistant bacteria and holds great promise for future clinical and environmental applications.

Automated summary

By reducing the dimensionality of the nanozymes, the catalytic activity is improved, leading to better antibacterial effects, wound healing promotion, and water environment disinfection.