Journal
INFLAMMOPHARMACOLOGY
Volume 24, Issue 5, Pages 291-293Publisher
SPRINGER BASEL AG
DOI: 10.1007/s10787-016-0283-2
Keywords
Neuroinflammation; Lipopolysaccharide; Time-dependent effects
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Lipopolysaccharide (LPS) administration has been repeatedly shown to elicit central inflammation, regardless of the route of administration. In a recent study, Tiwari et al. (Inflammopharmacology , 2016) dispute the potential of peripheral administration of LPS to induce neuroinflammation. Here, I summarise literature indicating that the neuroinflammatory effects of LPS are time dependent, and suggest that their findings can be explained by the time at which they chose to measure neuroinflammation.
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