Journal
INFECTIOUS DISEASES
Volume 48, Issue 11-12, Pages 823-828Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/23744235.2016.1201853
Keywords
Diabetes; respiratory infection; urinary tract infection; vitamin D
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Funding
- Novo Nordisk foundation [R195-A16126]
- North Norway Regional Health Authorities [6856/SFP1029-12]
- UiT The Arctic University of Norway
- Norwegian Diabetes Association
- Research Council of Norway [184766]
- Novo Nordisk Fonden [NNF12OC1016126] Funding Source: researchfish
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Background: In observational studies vitamin D deficiency is associated with increased risk of infections, whereas the effect of vitamin D supplementation in randomized controlled trials is non-conclusive. Methods: Five hundred and eleven subjects with prediabetes were randomized to vitamin D-3 (20,000IU per week) versus placebo for five years. Every sixth month, a questionnaire on respiratory tract infections (RTI) (common cold, bronchitis, influenza) and urinary tract infection (UTI) was filled in. Results: Mean baseline serum 25-hydroxyvitamin D (25(OH)D) level was 60nmol/L. Two hundred and fifty-six subjects received vitamin D and 255 placebo. One hundred and sixteen subjects in the vitamin D and 111 in the placebo group completed the five-year study. Eighteen subjects in the vitamin D group and 34 subjects in the placebo group reported UTI during the study (p<0.02), whereas no significant differences were seen for RTI. The effect on UTI was most pronounced in males. The effect of vitamin D on UTI was unrelated to baseline serum 25(OH)D level. Conclusion: Supplementation with vitamin D might prevent UTI, but confirmatory studies are needed.
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