Merging dearomatization with redox-neutral C(sp3)-H functionalization via hydride transfer/cyclization: recent advances and perspectives

Dearomatization and direct C(sp(3))-H functionalization represent two hot research fields in organic synthesis, the merging of which is among the most challenging but appealing topics. The emerging hydride transfer-involved dearomatization reaction can achieve this goal in an efficient redox-neutral manner, and encouraging progress has been made in this area during the past decade. Herein, we would like to give a timely account of the topic, and this review is categorized according to the hydride acceptors, namely vinylogous imines and quinone methides, which initiate the cascade hydride transfer/dearomative cyclization process to dearomatize indoles and phenols, respectively. Moreover, the limitations, challenges and future directions are also pointed out.

Automated summary

This review provides a timely account of the emerging hydride transfer-involved dearomatization reaction in organic synthesis. It categorizes the reaction based on different hydride acceptors, vinylogous imines and quinone methides, which initiate the cascade hydride transfer/dearomative cyclization process to dearomatize indoles and phenols. The limitations, challenges, and future directions in this field are also discussed.