Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 9, Issue 18, Pages 4969-4974Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo00919f
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Funding
- Research Grants Council of Hong Kong (NSFC/RGC Joint Research Scheme) [N_CUHK403/20]
- Chinese University of Hong Kong (Faculty of Science, Direct Grant for Research)
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We described a novel domino radical cyclization/bis(pentafluoroethylation) of 1,6-dienes for the synthesis of pyrrolidine and cyclopentane derivatives containing two C2F5 groups. This reaction efficiently constructs three carbon-carbon bonds in one step. The reagent [CuCF2CF3] is easily prepared from inexpensive pentafluoroethane and the reaction conveniently runs at room temperature in open air.
We herein describe a domino radical cyclization/bis(pentafluoroethylation) of 1,6-dienes for the synthesis of new classes of pyrrolidine and cyclopentane derivatives containing two C2F5 groups. This reaction is efficient for constructing three carbon-carbon bonds in one step. The reagent [CuCF2CF3] is prepared from inexpensive pentafluoroethane and the reactions conveniently run at room temperature in open air. Moderate to good diastereoselectivies can be obtained favouring the cis products with X-ray structural proof.
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