Journal
FUNGAL BIOLOGY REVIEWS
Volume 30, Issue 3, Pages 101-111Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.fbr.2016.06.001
Keywords
Carbon catabolite repression; Filamentous fungi; Lignocellulose degradation; Nutrient sensing; Transcriptional regulation; Unfolded protein response
Categories
Funding
- Energy Biosciences Institute
- Alexander von Humboldt research award
- National Institutes of Health NRSA Individual Postdoctoral Fellowship [5 F32 GM113372]
- National Science Foundation
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Lignocellulose is an abundant waste product of agricultural and processing industries that can be utilized as a renewable fuel substitute for petroleum-based fuels. Saprophytic filamentous fungi are an important source of plant cell wall degrading enzymes necessary to break down the complex carbohydrates found in plant cell walls into simple sugars. Zinc binuclear cluster transcription factors activate the transcription of plant cell wall degrading enzymes when fungal cells are exposed to plant biomass. Nutrient sensing pathways that prioritize the use of preferred carbon sources act upstream of these transcription factors to inhibit the energy intensive production of cell wall degrading enzymes when unnecessary, while downstream feedback from the fungal secretory system also acts to regulate the production of these enzymes. Understanding the regulation of the fungal lignocellulolytic response will be important as we strive to increase the efficiency of production of these enzymes. (C) 2016 British Mycological Society. Published by Elsevier Ltd. All rights reserved.
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