4.4 Review

Approaches to understanding protein hypersecretion in fungi

Journal

FUNGAL BIOLOGY REVIEWS
Volume 30, Issue 4, Pages 145-151

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.fbr.2016.06.002

Keywords

Aspergillus; Neurospora; Protein secretion; Trichoderma

Categories

Funding

  1. US Department of Energy, Office of Science, Office of Biological and Environmental Research [DE-AC02-05CH11231]

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Fungi are well known for secreting high levels of proteins. A number of strategies have been used to characterize and maximize protein secretion for industrial purposes. In this review, we highlight three different ascomycetes and focus on a specific protein production example for each. Aspergillus niger has been utilized as a production host for amylases and multiple molecular genetic approaches have been applied to increase secretion in this organism. Saccharification of plant biomass is an integral part of biofuel production and classical genetic and genomic approaches have been used in Trichoderma reesei to understand and manipulate the pathways controlling secretion of plant cell wall degrading enzymes. Finally, Neurospora crassa, a model filamentous ascomycete has been exploited to understand a wide range of biological processes including protein secretion. (C) 2016 Published by Elsevier Ltd on behalf of British Mycological Society.

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