☆ 4.7 Article

Understanding COVID-19-associated coagulopathy

NATURE REVIEWS IMMUNOLOGY (2022)

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The Role of Antiphospholipid Antibodies in COVID-19

Maximilian Stelzer et al.

Summary: The presence of anti-phospholipid antibodies in COVID-19 patients varies, with conflicting results on its significance in the disease. Further studies are needed to understand the role of APS in COVID-19 and strengthen the significance of comparisons made.

CURRENT RHEUMATOLOGY REPORTS (2021)

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Article Critical Care Medicine

Platelet activation in critically ill COVID-19 patients

Nader Yatim et al.

Summary: This study found that elevated soluble P-selectin levels at admission were associated with COVID-19 severity and could predict intubation and death. Gene expression analysis indicated that critically ill patients had increased expression of genes related to platelet activation, with specific genes showing grade-dependent upregulation. ROC curve analysis identified PPBP/CXCL7 and SELPLG as biomarkers for intubation.

ANNALS OF INTENSIVE CARE (2021)

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Article Immunology

Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins

Youssif M. Ali et al.

Summary: Early and persistent complement activation is crucial in the pathogenesis of COVID-19, leading to a series of pathological events that trigger severe inflammatory responses to SARS-CoV-2. Research targeting MASP-2 suggests that the LP pathway of the complement system could offer a therapeutic window for treating severe COVID-19.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

Platelets amplify endotheliopathy in COVID-19

Tessa J. Barrett et al.

Summary: The study reveals an inflammatory hypercoagulable state between platelets and endothelial cells in COVID-19, with platelet-released factors promoting endotheliopathy. S100A8, S100A9, and their protein product MRP8/14 are enriched in COVID-19 platelets and contribute significantly to poor clinical outcomes. Targeting platelet P2Y(12) appears to be a promising strategy for reducing proinflammatory platelet-endothelial interactions in COVID-19.

SCIENCE ADVANCES (2021)

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Article Medicine, General & Internal

Upregulation of pulmonary tissue factor, loss of thrombomodulin and immunothrombosis in SARS-CoV-2 infection

Ivo M. B. Francischetti et al.

Summary: This study found that COVID-19 patients have thrombotic and microvascular complications, and the coagulation abnormalities have a multifactorial etiology. Biomarkers of endothelial cell, neutrophil activation, and fibrinolysis were elevated in severe disease group, correlating with severity. Postmortem specimens demonstrated potential links to immunothrombosis with upregulation of pulmonary TF and loss of thrombomodulin staining.

ECLINICALMEDICINE (2021)

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Review Immunology

A scoping review of the pathophysiology of COVID-19

Paul E. Marik et al.

Summary: COVID-19 is a highly complex medical disorder, with severe cases involving multiple pathological processes such as inflammation, endothelial inflammation, and thrombosis. The presence of auto-antibodies exacerbates the severity of the disease.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2021)

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Review Pathology

COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury

Roberto F. Nicosia et al.

Summary: Critically ill COVID-19 patients develop vascular complications characterized by thrombosis in blood vessels of various sizes. Dysfunction of the vascular endothelium is mainly due to the indirect effects of the virus through cytokine storms and excessive immune response, rather than direct viral entry and infection of endothelial cells.

AMERICAN JOURNAL OF PATHOLOGY (2021)

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Article Public, Environmental & Occupational Health

Association between Circulating Protein C Levels and Incident Dementia: The Atherosclerosis Risk in Communities Study

Adrienne Tin et al.

Summary: This study found an inverse association between circulating protein C levels and incident dementia in both midlife and late life, independent of established risk factors. Further research on anticoagulants in relation to dementia may enhance our understanding of the connection between hemostasis and dementia.

NEUROEPIDEMIOLOGY (2021)

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Article Hematology

Comparison of the coagulopathies associated with COVID-19 and sepsis

Robert A. Campbell et al.

Summary: Patients with COVID-19 had significantly higher levels of D-dimer, EVTF activity, and active PAI-1 compared with healthy controls, while patients with sepsis had significantly higher levels of D-dimer and EVTF activity compared with healthy controls. High levels of both EVTF activity and active PAI-1 in COVID-19 patients may promote thrombosis due to simultaneous activation of coagulation and inhibition of fibrinolysis, and the high levels of active PAI-1 may explain the lower levels of D-dimer in COVID-19 patients compared with sepsis patients.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2021)

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Article Immunology

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

Aldo Bonaventura et al.

Summary: The authors suggest that SARS-CoV-2 infection induces a prothrombotic state and dysregulated immunothrombosis, leading to severe manifestations of COVID-19. They also discuss potential antithrombotic and immunomodulating drugs for treating COVID-19 patients, aiming to reduce the acute and long-term consequences of the disease by targeting immunothrombosis.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Critical Care Medicine

Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients

Yue Zhang et al.

Summary: The study found that plasma levels of complements C3 and MPO-DNA were positively correlated with coagulation indicators in COVID-19 patients. The complement components anaphylatoxins in the plasma of COVID-19 patients strongly induced NET formation. Early intervention in anaphylatoxins might help prevent thrombosis and disease progression in COVID-19 patients.

CRITICAL CARE (2021)

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Review Clinical Neurology

Stroke in COVID-19: A systematic review and meta-analysis

Stefania Nannoni et al.

Summary: Acute cerebrovascular diseases occur in 1.4% of COVID-19 patients, with acute ischemic stroke being the most common manifestation. Patients with COVID-19 are more likely to have pre-existing vascular risk factors and higher mortality rates compared to those without cerebrovascular diseases.

INTERNATIONAL JOURNAL OF STROKE (2021)

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Article Hematology

Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

Ning Tang et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Medicine, General & Internal

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

Nanshan Chen et al.

LANCET (2020)

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Article Medicine, General & Internal

Clinical Characteristics of Coronavirus Disease 2019 in China

W. Guan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Medicine, General & Internal

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

Dominic Wichmann et al.

ANNALS OF INTERNAL MEDICINE (2020)

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Article Hematology

COVID-19 and its implications for thrombosis and anticoagulation

Jean M. Connors et al.

BLOOD (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

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Article Cardiac & Cardiovascular Systems

Deep Vein Thrombosis in Hospitalized Patients With COVID-19 in Wuhan, China Prevalence, Risk Factors, and Outcome

Li Zhang et al.

CIRCULATION (2020)

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Letter Virology

Elevated level of C-reactive protein may be an early marker to predict risk for severity of COVID-19

Nurshad Ali

JOURNAL OF MEDICAL VIROLOGY (2020)

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Article Clinical Neurology

SARS-CoV-2 and Stroke in a New York Healthcare System

Shadi Yaghi et al.

STROKE (2020)

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Article Medical Laboratory Technology

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases

Cynthia Magro et al.

TRANSLATIONAL RESEARCH (2020)

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Editorial Material Hematology

Thromboinflammation and the hypercoagulability of COVID-19

Jean M. Connors et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Hematology

Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia

Songping Cui et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Biology

Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

Frank L. van de Veerdonk et al.

ELIFE (2020)

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Letter Medicine, General & Internal

Electron microscopy of SARS-CoV-2: a challenging task

Cynthia S. Goldsmith et al.

LANCET (2020)

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Letter Medicine, General & Internal

Endothelial cell infection and endotheliitis in COVID-19

Zsuzsanna Varga et al.

LANCET (2020)

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Article Medicine, General & Internal

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou et al.

LANCET (2020)

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Article Multidisciplinary Sciences

Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

Sin Fun Sia et al.

NATURE (2020)

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Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Cardiac & Cardiovascular Systems

Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy

Leo Nicolai et al.

CIRCULATION (2020)

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Letter Cardiac & Cardiovascular Systems

Platelet and Vascular Biomarkers Associate With Thrombosis and Death in Coronavirus Disease

Tessa J. Barrett et al.

CIRCULATION RESEARCH (2020)

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Article Hematology

Endothelial Dysfunction and Thrombosis in Patients With COVID-19-Brief Report

Seigo Nagashima et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

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Article Hematology

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

Elizabeth A. Middleton et al.

BLOOD (2020)

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Article Hematology

Platelet gene expression and function in patients with COVID-19

Bhanu Kanth Manne et al.

BLOOD (2020)

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Review Cardiac & Cardiovascular Systems

Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science

Paul C. Evans et al.

CARDIOVASCULAR RESEARCH (2020)

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Article Immunology

Understanding the Pathophysiology of COVID-19: Could the Contact System Be the Key?

Simone Meini et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Hematology

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

George Goshua et al.

LANCET HAEMATOLOGY (2020)

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Article Medicine, Research & Experimental

Neutrophil extracelluar traps in COVID-19

Yu Zuo et al.

JCI INSIGHT (2020)

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Letter Medicine, General & Internal

Venous Thrombosis Among Critically Ill Patients With Coronavirus Disease 2019 (COVID-19)

Julien Nahum et al.

JAMA NETWORK OPEN (2020)

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Article Hematology

Influenza-induced thrombocytopenia is dependent on the subtype and sialoglycan receptor and increases with virus pathogenicity

A. J. Gerard Jansen et al.

BLOOD ADVANCES (2020)

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Review Cardiac & Cardiovascular Systems

Incidence of Venous Thromboembolism in Hospitalized Coronavirus Disease 2019 Patients: A Systematic Review and Meta-Analysis

Chi Zhang et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2020)

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Article

COVID-19 et pathologie thromboembolique veineuse

A. Trimaille et al.

ANNALES DE CARDIOLOGIE ET D ANGEIOLOGIE (2020)

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Article Hematology

Identification of hemostatic markers that define the pre-DIC state: A multi-center observational study

Nicholas L. Jackson Chornenki et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Hematology

In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID-19 patients on anticoagulation

Annabel Blasi et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Review Hematology

Is the COVID-19 thrombotic catastrophe complement-connected?

Edward M. Conway et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Hematology

Hypofibrinolytic state and high thrombin generation may play a major role in SARS-COV2 associated thrombosis

Christophe Nougier et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Hematology

Platelets Promote Thromboinflammation in SARS-CoV-2 Pneumonia

Francesco Taus et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

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Article Hematology

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

Jia Yu et al.

BLOOD (2020)

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Article Hematology

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19

Eugenio D. Hottz et al.

BLOOD (2020)

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Article Biochemistry & Molecular Biology

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

Sarah R. Leist et al.

CELL (2020)

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Article Cardiac & Cardiovascular Systems

Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19

Younes Zaid et al.

CIRCULATION RESEARCH (2020)

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Article Multidisciplinary Sciences

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

Masaki Imai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Medicine, Research & Experimental

Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis

Panagiotis Skendros et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Immunology

SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology

Flavio Protasio Veras et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Article Multidisciplinary Sciences

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

Kenneth H. Dinnon et al.

NATURE (2020)

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Review Multidisciplinary Sciences

Animal models for COVID-19

Cesar Munoz-Fontela et al.

NATURE (2020)

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Article Immunology

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

Emma S. Winkler et al.

NATURE IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients

Jan C. Holter et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Review Hematology

Mechanisms involved in the development of thrombocytopenia in patients with COVID-19

Yujiao Zhang et al.

THROMBOSIS RESEARCH (2020)

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Article Virology

Intranasal exposure of African green monkeys to SARS-CoV-2 results in acute phase pneumonia with shedding and lung injury still present in the early convalescence phase

Robert W. Cross et al.

VIROLOGY JOURNAL (2020)

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Letter Medicine, Research & Experimental

Zilucoplan in patients with acute hypoxic respiratory failure due to COVID-19 (ZILU-COV): A structured summary of a study protocol for a randomised controlled trial

Jozefien Declercq et al.

TRIALS (2020)

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Review Physiology

The Expanding Cell Diversity of the Brain Vasculature

Jayden M. Ross et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Medicine, General & Internal

MicroCLOTS pathophysiology in coronavirus disease 2019

Samuele Renzi et al.

KOREAN JOURNAL OF INTERNAL MEDICINE (2020)

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Article Cell Biology

Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19

Yu Zuo et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Medicine, General & Internal

Covid-19-Associated Coagulopathy: Biomarkers of Thrombin Generation and Fibrinolysis Leading the Outcome

Marco Ranucci et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Immunology

Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy

Dimitrios C. Mastellos et al.

CLINICAL IMMUNOLOGY (2020)

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Article Hematology

COVID-19 hypothesis: Activated protein C for therapy of virus-induced pathologic thromboinflammation

John H. Griffin et al.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2020)

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Article Hematology

Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3

Robert A. Campbell et al.

BLOOD (2019)

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Review Biology

Synthetic glycoscapes: addressing the structural and functional complexity of the glycocalyx

Sean C. Purcell et al.

INTERFACE FOCUS (2019)

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Article Hematology

TNF-α driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging

Pavel Davizon-Castillo et al.

BLOOD (2019)

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Article Physiology

Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg(9) bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration

Chhinder P. Sodhi et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2018)

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Review Hematology

Activated protein C, protease activated receptor 1, and neuroprotection

John H. Griffin et al.

BLOOD (2018)

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Review Biochemistry & Molecular Biology

Bifunctional ligands of the bradykinin B2 and B1 receptors: An exercise in peptide hormone plasticity

Francois Marceau et al.

PEPTIDES (2018)

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Article Cell Biology

Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction

John D. Eicher et al.

PLATELETS (2016)

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Review Immunology

Neutrophil extracellular Traps in Pulmonary Diseases: Too Much of a Good Thing?

Barbara Nery Porto et al.

FRONTIERS IN IMMUNOLOGY (2016)

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Review Hematology

Reincarnation of ancient links between coagulation and complement

E. M. Conway

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2015)

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Article Microbiology

Mechanisms of Severe Acute Respiratory Syndrome Coronavirus-Induced Acute Lung Injury

Lisa E. Gralinski et al.

MBIO (2013)

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Review Immunology

Thrombosis as an intravascular effector of innate immunity

Bernd Engelmann et al.

NATURE REVIEWS IMMUNOLOGY (2013)

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Article Critical Care Medicine

In Vivo Platelet Activation in Critically III Patients With Primary 2009 Influenza A(H1N1)

Matthew T. Rondina et al.

CHEST (2012)

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Article Virology

Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63

Ilona Glowacka et al.

JOURNAL OF VIROLOGY (2010)

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Article Hematology

Low protein C and incidence of ischemic stroke and coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) Study

A. R. Folsom et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2009)

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Article Cell Biology

SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway

Hongliang Wang et al.

CELL RESEARCH (2008)

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Article Virology

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus

Paul B. McCray et al.

JOURNAL OF VIROLOGY (2007)

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Article Multidisciplinary Sciences

Angiotensin-converting enzyme 2 protects from severe acute lung failure

Y Imai et al.

NATURE (2005)

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Article Critical Care Medicine

Low levels of protein C are associated with poor outcome in severe sepsis

SB Yan et al.

CHEST (2001)

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