Journal
FRONTIERS OF MEDICINE
Volume 10, Issue 1, Pages 33-40Publisher
SPRINGER
DOI: 10.1007/s11684-016-0431-5
Keywords
cancer-associated fibroblast; breast cancer; progression; prognosis
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Funding
- National Natural Science Foundation of China [30930038]
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Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increased in recent years because of changes in diet, living environment, gestational age, and other unknown factors. Previous studies focused on cancer cells, but an increasing number of recent studies have analyzed the contribution of cancer microenvironment to the initiation and progression of breast cancer. Cancer-associated fibroblasts (CAFs), the most abundant cells in tumor stroma, secrete various active biomolecules, including extracellular matrix components, growth factors, cytokines, proteases, and hormones. CAFs not only facilitate the initiation, growth, angiogenesis, invasion, and metastasis of cancer but also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of breast cancer. In this article, we reviewed the literature and summarized the research findings on CAFs in breast cancer.
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