Journal
FRONTIERS OF MEDICINE
Volume 10, Issue 3, Pages 237-249Publisher
SPRINGER
DOI: 10.1007/s11684-016-0464-9
Keywords
inner ear; cochlea; hair cell; regeneration; Wnt; Notch; signaling pathways
Categories
Funding
- National Basic Research Program of China (973 Program) [2015CB965000]
- National Natural Science Foundation of China [81570911, 81470692, 81470687, 81371094, 81230019, 81500790, 81570921, 31500852, 31501194]
- Jiangsu Province Natural Science Foundation [BK20150022, BK20140620, BK20150598]
- Fundamental Research Funds for the Central Universities [2242014R30022, 021414380037]
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Sensory hair cells in the inner ear are responsible for sound recognition. Damage to hair cells in adult mammals causes permanent hearing impairment because these cells cannot regenerate. By contrast, newborn mammals possess limited regenerative capacity because of the active participation of various signaling pathways, including Wnt and Notch signaling. The Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multiple cellular events necessary for the formation of sensory hair cells. Both signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochlea. In this regard, Wnt and Notch signaling has gained increased research attention in hair cell regeneration. This review presents the current understanding of the Wnt and Notch signaling pathways in the auditory portion of the inner ear and discusses the possibilities of controlling these pathways with the hair cell fate determiner Atoh1 to regulate hair cell regeneration in the mammalian cochlea.
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