Selective detection of tartaric acid using amino acid interlinked silver nanoparticles as a colorimetric probe

A variety of biomolecules with different functional groups play critical roles in almost all the processes occurring in living cells. Interaction of metallic nanoparticles (NPs) with various biomolecules generates a layer of molecules on their surface, and this biomolecular rich layer formed on the NP surface is described as a biomolecular corona. The physicochemical properties of the NPs, including size, adsorption affinity, and charge on the particles' surfaces are the major factors influencing the characteristics of this corona. The formation of various biomolecular corona has been studied well, whereas the amino acid corona is relatively new by exploring their stability. In the present study, a novel formation of an amino acid corona with a fundamental interaction mechanism for a selective detection procedure using a colorimetric platform has been proposed. Herein, amino acid-coated silver NPs (AgNPs) have been used as a template with spectroscopic (steady state UV-Vis, FTIR) and imaging (HR-TEM, DLS) techniques. Our findings demonstrated that among different amino acid coronas, glutathione (GSH) stabilized AgNPs show a rapid reaction with tartaric acid. The extent and thermodynamics of the formed complex between the GSH/AgNPs and tartaric acid have also been studied and this suggested that the complex formed is spontaneous and energy releasing in nature.

Automated summary

The interaction of biomolecules with metallic nanoparticles generates a biomolecular corona on the NP surface, with the amino acid corona being a relatively new research subject that shows potential for selective detection applications. Through spectroscopic and imaging techniques, the interaction mechanism and thermodynamic properties of the complex formed between glutathione-stabilized silver nanoparticles and tartaric acid have been explored.