Journal
EUROPEAN JOURNAL OF PEDIATRICS
Volume 181, Issue 10, Pages 3711-3714Publisher
SPRINGER
DOI: 10.1007/s00431-022-04578-6
Keywords
Near-infrared spectroscopy; Cerebral oxygenation; Preterm infants; Neurodevelopment; Psychomotor outcome; Griffiths scales
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Funding
- Alma Mater Studiorum Universita di Bologna within the CRUI-CARE Agreement
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This observational study found a significant correlation between predischarge cerebral oxygenation (CrSO2) and psychomotor development in very preterm infants at 6 months, but not in later assessments. The correlation remained significant even after adjusting for relevant covariates. Therefore, predischarge CrSO2 may not be an effective predictor for medium-term neurodevelopment.
This observational study aimed to investigate whether predischarge cerebral oxygenation (CrSO2), monitored by near-infrared spectroscopy, correlates with later psychomotor outcome in very preterm infants. Infants <32 weeks' gestation or <1500 g without evidence of major brain lesions underwent a 3-h continuous CrSO2 monitoring before hospital discharge. Psychomotor development was assessed at 6, 12, 18, and 24 months using the Griffiths Mental Developmental Scales. The developmental quotients (DQ) at each follow-up appointment were correlated with predischarge CrSO2. Significant correlations were adjusted for possible confounders. Sixty-three infants were enrolled. A significant correlation between CrSO2 and DQ was observed at 6 months ca (p=0.010), but not at later psychomotor assessments. This correlation was confirmed significant (b=0.274, p=0.038) even after the adjustment for relevant covariates. Conclusion: According to these preliminary findings, the association between predischarge CrSO2 and psychomotor development over the first 24 months in preterm infants without major brain lesions is time-limited. Hence, this parameter may not represent an effective predictor for medium-term neurodevelopment.
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