White matter microstructural integrity pre- and post-treatment in individuals with chronic post-stroke aphasia

While previous studies have found that white matter damage relates to impairment severity in individuals with aphasia, further study is required to understand the relationship between white matter integrity and treatment response. In this study, 34 individuals with chronic post-stroke aphasia underwent behavioral testing and structural magnetic resonance imaging at two timepoints. Thirty participants within this sample completed typicality-based semantic feature treatment for anomia. Tractography of bi-hemispheric white matter tracts was completed via Automated Fiber Quantification. Associations between microstructural integrity metrics and behavioral measures were evaluated at the tract level and in nodes along the tract. Diffusion measures of the left inferior longitudinal, superior longitudinal, and arcuate fasciculi were related to aphasia severity and diffusion measures of the left inferior longitudinal fasciculus were related to naming and treatment response. This study also found preliminary evidence of left inferior longitudinal fasciculus microstructural changes following treatment.

Automated summary

Previous studies have shown that white matter damage is related to the severity of aphasia, but further research is needed to understand the relationship between white matter integrity and treatment response. In this study, it was found that the diffusion measures of the left inferior longitudinal fasciculus were related to aphasia severity and treatment response, with microstructural changes observed following treatment.