Journal
FRONTIERS IN IMMUNOLOGY
Volume 7, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2016.00481
Keywords
antigen presentation; antigen-presenting cells; B cells; dendritic cells; follicular dendritic cells; macrophages; tertiary lymphoid organs
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Funding
- British Heart Foundation [PG/06/083/21198, PG/12/81/29897, RE/13/5/30177]
- Medical Research Scotland [276 FRG-L-0806]
- European Commission Marie Sklodowska-Curie Individual Fellowships [661369]
- Nuffield Foundation
- Arthritis Research UK [20298]
- Marie Curie Actions (MSCA) [661369] Funding Source: Marie Curie Actions (MSCA)
- British Heart Foundation [PG/12/81/29897] Funding Source: researchfish
- Versus Arthritis [19788] Funding Source: researchfish
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Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells and mechanisms of antigen presentation in TLOs, summarizing what is currently known about this facet of the formation and function of these tissues as well as identifying questions yet to be addressed.
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