Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 70, Pages 9802-9805Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc03296a
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Funding
- National Natural Science Foundation of China [22074128, 21521004]
- Fundamental Research Funds for the Central Universities [20720210013, 20720220005]
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Novel cell-targeting ligand structures with high avidity and low dosage have been constructed, which provide potential possibilities for applications such as cell detection and drug delivery.
Novel cell-targeting ligand structures are constructed with a spikey core scaffold, where multiple copies of coiled-coil peptide nanorods are conjugated on the surface of a peptide nanosheet. Clustering of carbohydrate and aptamer ligands at the end of the coiled coils optimizes ligand accessibility to cell-surface receptors. Display of the ligand-coil conjugates on the nanosheet generates a patchy ligand pattern bearing two levels of multivalency. With the ligand-scaffold system, high-avidity cell targeting is realized using fewer ligands than ever, which facilitates future applications in cell detection and drug delivery.
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