Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 71, Pages 9938-9941Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc03156f
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Funding
- U.S. DOE Isotope Program
- Laboratory Directed Research and Development Program of ORNL
- U.S. Department of Energy [DE-AC05-00OR22725]
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In this study, we report the complexation thermodynamics of Ra2+ with two biomedically-relevant chelators, DOTA and macropa. Our findings reveal the highest affinity chelator for Ra2+ to date and advance our understanding of key factors determining complex stability and selectivity for this underexplored ion.
The coordination chemistry of Ra2+ is poorly defined, hampering efforts to design effective chelators for Ra-223-based targeted alpha therapy. Here, we report the complexation thermodynamics of Ra2+ with the biomedically-relevant chelators DOTA and macropa. Our work reveals the highest affinity chelator to date for Ra2+ and advances our understanding of key factors underlying complex stability and selectivity for this underexplored ion.
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