Journal
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
Volume 21, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/15330338221117386
Keywords
microRNAs; osteosarcoma; biomarkers; targeted therapy; molecular mechanisms
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Funding
- Gansu Provincial Party Committee Organization Department 2021 Longyuan Youth Innovation and Entrepreneurship Talent Project [21LQTD26]
- Youth Project of Natural Science Foundation of Gansu Province [21JR1RA098]
- Health Industry Scientific Research And Management Project of Health Commission of Gansu Province [GSWSKY2019-73]
- Hospital Fund project of Lanzhou University First Hospital [ldyyyn2018-01]
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This paper reviews the role of microRNAs in the pathogenesis of osteosarcoma and their clinical value, aiming to provide a new research direction for diagnosing and treating osteosarcoma and achieving a better prognosis.
Osteosarcoma is one of the most common primary malignant bone tumors, mainly occurring in children and adolescents, and is characterized by high morbidity and poor prognosis. MicroRNAs, a class of noncoding RNAs consisting of 19 to 25 nucleotides, are involved in cell proliferation, invasion, metastasis, and apoptosis to regulate the development and progression of osteosarcoma. Studies have found that microRNAs are closely related to the diagnosis, treatment, and prognosis of osteosarcoma patients and have an important role in improving drug resistance in osteosarcoma. This paper reviews the role of microRNAs in the pathogenesis of osteosarcoma and their clinical value, aiming to provide a new research direction for diagnosing and treating osteosarcoma and achieving a better prognosis.
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