Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 70, Pages 9822-9825Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc03115a
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Funding
- Science and Engineering Research Board (SERB), India
- UGC, India
- CSIR, India
- PMRF
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This paper reports for the first time an Ir-catalyzed tandem synthesis of various N-methylated tertiary amines through a three-component coupling of carbonyl compounds, amines, and methanol followed by reductive amination/N-methylation. The method demonstrates a wide range of substrate tolerance towards different functional groups and can be applied to the synthesis of pharmaceutically important drug molecules containing N-methyl groups.
An Ir-catalyzed tandem synthesis of various N-methylated tertiary amines from three-component coupling of carbonyl compounds, amines, and methanol following reductive amination/N-methylation is reported for the first time. A wide array of substrates with tolerance of different functional groups was demonstrated. The protocol was extended to the synthesis of N-methyl containing pharmaceutically important drug molecules. A probable catalytic cycle was proposed based on various control experiments and different analytical techniques such as NMR, IR and ESI-MS.
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