Journal
MOLECULAR OMICS
Volume 18, Issue 8, Pages 814-820Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2mo00100d
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Funding
- Department of Biotechnology, Govt India
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Diagnosing bacterial coinfections with COVID-19 is challenging due to the limited specificity of the gold-standard culture sensitivity test. A gene signature and qPCR-based score have been developed to accurately diagnose these cases and guide the clinical use of antibiotics.
Confirmatory diagnosis of bacterial coinfections with COVID-19 is challenging due to the limited specificity of the widely used gold-standard culture sensitivity test despite clinical presentations. A misdiagnosis can either lead to increased health complications or overuse of antibiotics in COVID-19 patients. With a multi-step systems biology pipeline, we have identified a 9-gene biomarker panel from host blood that can identify bacterial coinfection in COVID-19 patients, even in culture-negative cases. We have also formulated a qPCR-based score that diagnoses bacterial coinfection with COVID-19 with the accuracy, specificity, and sensitivity of 0.93, 0.96, and 0.89, respectively. This gene signature and score can assist in the clinical decision-making process of necessary and timely prescription of antibiotics in suspected bacterial coinfection cases with COVID-19 and thereby help to reduce the associated morbidity and mortality.
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