4.6 Article

Combination of the lateral-flow immunoassay with multicolor gold nanorod etching for the semi-quantitative detection of digoxin

Journal

ANALYST
Volume 147, Issue 18, Pages 4000-4007

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d2an01047j

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Funding

  1. Precise Advanced Technologies and Health Systems for Underserved Populations (PATHS-UP) Engineering Research Center (ERC) - National Science Foundation (NSF) [1648451]

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This study is the first to combine lateral-flow immunoassay with gold nanorod etching, achieving a multicolor readout that is correlated with digoxin concentrations in human serum, within the range of 0.5-3.0 ng mL(-1), for therapeutic drug monitoring.
We are the first to combine the lateral-flow immunoassay (LFA) with gold nanorod (GNR) etching to achieve a multicolor readout where the color produced was correlated with digoxin concentrations in human serum in the relevant range for therapeutic drug monitoring of 0.5-3.0 ng mL(-1).

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