Journal
PSYCHOLOGICAL MEDICINE
Volume 52, Issue 11, Pages 2052-2061Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291720003876
Keywords
Dynamic regional homogeneity; gene expression; imaging genetics; major depressive disorder; weighted gene co-expression network analysis
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Funding
- National Key Research and Development Program of China [2018YFC1314300]
- National Natural Science Foundation of China [82030053, 82072001]
- Tianjin Key Technology RD Program [17ZXMFSY00090]
- Natural Science Foundation of Tianjin Municipal Science and Technology Commission [18JCQNJC10900]
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Patients with major depressive disorder (MDD) show reduced dynamic regional homogeneity (dReHo) in brain areas associated with emotional and cognitive regulation. These alterations may be related to complex polygenetic and polypathway mechanisms.
Background Major depressive disorder (MDD) is a common debilitating disorder characterized by impaired spontaneous brain activity, yet little is known about its alterations in dynamic properties and the molecular mechanisms associated with these changes. Methods Based on the resting-state functional MRI data of 65 first-episode, treatment-naive patients with MDD and 66 healthy controls, we compared dynamic regional homogeneity (dReHo) of spontaneous brain activity between the two groups, and we investigated gene expression profiles associated with dReHo alterations in MDD by leveraging transcriptional data from the Allen Human Brain Atlas and weighted gene co-expression network analysis. Results Compared with healthy controls, patients with MDD consistently showed reduced dReHo in both fusiform gyri and in the right temporal pole and hippocampus. The expression profiles of 16 gene modules were correlated with dReHo alterations in MDD. These gene modules were enriched for various biological process terms, including immune, synaptic signalling, ion channels, mitochondrial function and protein metabolism, and were preferentially expressed in different cell types. Conclusions Patients with MDD have reduced dReHo in brain areas associated with emotional and cognitive regulation, and these changes may be related to complex polygenetic and polypathway mechanisms.
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