Journal
POLYMER CHEMISTRY
Volume 13, Issue 36, Pages 5234-5242Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2py00505k
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Funding
- Ministry of Science and ICT, Ministry of Education
- National Research Foundation of Korea through the Basic Science Research Program [2019R1I1A2A01040856, 2022R1A2C2008256]
- National Research Foundation of Korea [2019R1I1A2A01040856, 2022R1A2C2008256] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This study developed a pH-sensitive ampicillin-loaded double-network hydrogel for local delivery of antibiotics against Gram-positive bacteria. The hydrogel exhibited excellent biocompatibility and antimicrobial activity, making it suitable for in situ delivery of antibiotics in post-operative patients.
This paper describes the development of a pH-sensitive ampicillin-loaded double-network hydrogel for the local delivery of antibiotics against Gram-positive bacteria. Covalent polymerization of a cationic monomer constituted the first network, whereas imine bond formation between the aldehyde end group of Pluronic F127 (F127-CHO) and the amine of polyethyleneimine constituted the second network. The hydrogel was loaded with the antibiotic ampicillin. Ampicillin was conjugated by forming a reversible imine bond with F127-CHO, which allowed its sustained release over an extended period of time. The antibiotic's release was dependent on the initial amount of drug conjugated in the hydrogel and was greater at pH 5 than at pH 7. The hydrogel displayed excellent biocompatibility and antimicrobial activity against Gram-positive bacteria in vitro. Therefore, in the future, the proposed hydrogel could be used for in situ delivery of antibiotics in post-operative patients.
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