Journal
BONE RESEARCH
Volume 10, Issue 1, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s41413-022-00224-x
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Funding
- National Natural Science Foundation of China [81921002, 81900970, 82130027]
- Young Physician Innovation Team Project from Ninth People's Hospital [QC202003]
- Shanghai Jiao Tong University School of Medicine
- Shanghai Sailing Program [19YF1426000]
- Young Elite Scientists Sponsorship Program CAST [2018QNRC001]
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This study aimed to fabricate bioactive scaffolds by incorporating strontium into modified amino-functional mesoporous bioactive glass (MBG) and investigate their bioactivity in vitro and in vivo. The results showed that the strontium-incorporated scaffolds had good biocompatibility and enhanced osteogenic and angiogenic capacities. In addition, bioinformatics analysis suggested that the scaffolds could reduce reactive oxygen species levels in bone marrow mesenchymal stem cells in the osteoporotic model, playing an anti-osteoporosis role while promoting osteogenesis.
The restoration of bone defects caused by osteoporosis remains a challenge for surgeons. Strontium ranelate has been applied in preventative treatment approaches due to the biological functions of the trace element strontium (Sr). In this study, we aimed to fabricate bioactive scaffolds through Sr incorporation based on our previously developed modified amino-functional mesoporous bioactive glass (MBG) and to systematically investigate the bioactivity of the resulting scaffold in vitro and in vivo in an osteoporotic rat model. The results suggested that Sr-incorporated amino-functional MBG scaffolds possessed favorable biocompatibility. Moreover, with the incorporation of Sr, osteogenic and angiogenic capacities were upregulated in vitro. The in vivo results showed that the Sr-incorporated amino-functional MBG scaffolds achieved better bone regeneration and vessel formation. Furthermore, bioinformatics analysis indicated that the Sr-incorporated amino-functional MBG scaffolds could reduce reactive oxygen species levels in bone marrow mesenchymal stem cells in the osteoporotic model by activating the cAMP/PKA signaling pathway, thus playing an anti-osteoporosis role while promoting osteogenesis. This study demonstrated the feasibility of incorporating trace elements into scaffolds and provided new insights into biomaterial design for facilitating bone regeneration in the treatment of osteoporosis.
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