4.7 Article

Chiral gold(III) complexes: speciation, in vitro, and in vivo anticancer profile

Journal

CHEMICAL COMMUNICATIONS
Volume 58, Issue 73, Pages 10237-10240

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc03081k

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The emerging synthetic development of chiral gold(III) complexes has shown new opportunities in catalysis and material science, and this study demonstrates the potential chemotherapeutic capability of a specific gold(III) complex.
Emerging synthetic development of chiral gold(III) complexes has prompted new opportunities in catalysis and material science with limited utility in biomedicine. Here, we demonstrate potential chemotherapeutic capability of [C<^>N]Au(III)Cl(R-DuPhos) (1-7) complexes, containing 1,2-bis[(2R,5R)-2,5-dialkylphospholano]benzene, which shows good stabilty, potent anticancer activity, and tolerability in mice.

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