Journal
CURRENT OSTEOPOROSIS REPORTS
Volume 14, Issue 6, Pages 337-344Publisher
SPRINGER
DOI: 10.1007/s11914-016-0336-x
Keywords
Diabetes; Bone marrow fat; Osteoporosis; Marrow adipose tissue
Categories
Funding
- National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK)
- National Institutes of Health (NIH) [5T32 DK007418-35]
- Department of Veterans Affairs
- Veterans Health Administration
- Clinical Science Research and Development Service
- Career Development [5 IK2 CX000549]
- NIDDK
- NIH [R01 DK107629]
- American Society for Bone
- Mineral Research (Junior Faculty Osteoporosis Clinical Research Award)
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This study aims to describe bone marrow fat changes in diabetes and to discuss the potential role of marrow fat in skeletal fragility. Advances in non-invasive imaging have facilitated marrow fat research in humans. In contrast to animal studies which clearly demonstrate higher levels of marrow fat in diabetes, human studies have shown smaller and less certain differences. Marrow fat has been reported to correlate with A1c, and there may be a distinct marrow lipid saturation profile in diabetes. Greater marrow fat is associated with impaired skeletal health. Marrow fat may be a mediator of skeletal fragility in diabetes. Circulating lipids, growth hormone alterations, visceral adiposity, and hypoleptinemia have been associated with greater marrow fat and may represent potential mechanisms for the putative effects of diabetes on marrow fat, although other factors likely contribute. Additional research is needed to further define the role of marrow fat in diabetic skeletal fragility and to determine whether marrow fat is a therapeutic target.
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