Journal
CURRENT OPINION IN INSECT SCIENCE
Volume 18, Issue -, Pages 1-10Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cois.2016.08.001
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Funding
- National Institute for Neurological Disease and Stroke of the National Institutes of Health [RO1 AG025525, R21 NS078363]
- OHSU Presidential Bridge Funding Award
- Oregon Partners for Alzheimer's Research
- National Institute on Aging, National Institutes of Health [T32 AG023477]
- National Institutes of Health [P30 NS061800]
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The Amyloid Precursor Protein (APP) is the source of amyloid peptides that accumulate in Alzheimer's disease. However, members of the APP family are strongly expressed in the developing nervous systems of invertebrates and vertebrates, where they regulate neuronal guidance, synaptic remodeling, and injury responses. In contrast to mammals, insects express only one APP ortholog (APPL), simplifying investigations into its normal functions. Recent studies have shown that APPL regulates neuronal migration in the developing insect nervous system, analogous to the roles ascribed to APP family proteins in the mammalian cortex. The comparative simplicity of insect systems offers new opportunities for deciphering the signaling mechanisms by which this enigmatic class of proteins contributes to the formation and function of the nervous system.
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