Journal
BIOENGINEERED
Volume 7, Issue 3, Pages 155-165Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/21655979.2016.1191707
Keywords
immunogenicity; Pichia pastoris; protective efficacy; recombinant expression; subunit vaccine
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Funding
- Promotive Research Fund for Excellent Young and Middle-Aged Scientists of Shandong Province [BS2014YY042]
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Recombinant protein subunit vaccines are formulated using defined protein antigens that can be produced in heterologous expression systems. The methylotrophic yeast Pichia pastoris has become an important host system for the production of recombinant subunit vaccines. Although many basic elements of P. pastoris expression system are now well developed, there is still room for further optimization of protein production. Codon bias, gene dosage, endoplasmic reticulum protein folding and culture condition are important considerations for improved production of recombinant vaccine antigens. Here we comment on current advances in the application of P. pastoris for the synthesis of recombinant subunit vaccines.
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