4.7 Article

Stigmasterol attenuates hepatic steatosis in rats by strengthening the intestinal barrier and improving bile acid metabolism

Related references

Note: Only part of the references are listed.
Article Nutrition & Dietetics

The Intestinal Microbiome Predicts Weight Loss on a Calorie-Restricted Diet and Is Associated With Improved Hepatic Steatosis

Tien S. Dong et al.

Summary: The study found that participants who lost at least 5% of their body weight showed significant reduction in serum triglyceride and hepatic steatosis, with changes in certain microbiota composition at the end of the trial. Baseline microbiome differences were able to predict weight loss of at least 5% accurately.

FRONTIERS IN NUTRITION (2021)

Article Environmental Sciences

Propamocarb exposure has the potential to accelerate the formation of atherosclerosis in both WT and ApoE-/- mice accompanied by gut microbiota dysbiosis

Cuiyuan Jin et al.

Summary: Propamocarb exposure may accelerate the formation of atherosclerosis by increasing blood lipid levels, disrupting cholesterol metabolism, promoting lipid deposition, and altering inflammatory responses and gut microbiota composition.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Immunology

Stigmasterol Restores the Balance of Treg/Th17 Cells by Activating the Butyrate-PPARγ Axis in Colitis

Shuting Wen et al.

Summary: Stigmasterol treatment restores the Treg/Th17 balance and alters the gut microbiota, while also enhancing the production of SCFAs, particularly butyrate. Mechanistically, butyrate activates PPAR gamma and reprograms energy metabolism to promote Treg differentiation and inhibit Th17 differentiation, thus attenuating IBD.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Interleukin-22 Deficiency Contributes to Dextran Sulfate Sodium-Induced Inflammation in Japanese Medaka, Oryzias latipes

Yoshie Takahashi et al.

Summary: This study on Japanese medaka revealed that IL-22 is crucial for maintaining intestinal homeostasis and plays a significant role in promoting intestinal healing and preventing exacerbation of inflammatory pathology.

FRONTIERS IN IMMUNOLOGY (2021)

Review Cell Biology

Bile Acid Receptors and the Gut-Liver Axis in Nonalcoholic Fatty Liver Disease

Rui Xue et al.

Summary: The prevalence of NAFLD has increased due to obesity epidemic, with disease progression linked to inflammation, insulin resistance, and dysbiosis. Efforts to understand the mechanisms remain incomplete, but targeting BA-mediated signaling pathways offers potential for therapeutic development.

CELLS (2021)

Article Cell Biology

A New Strain of Christensenella minuta as a Potential Biotherapy for Obesity and Associated Metabolic Diseases

Wilfrid Mazier et al.

Summary: The study showed that Christensenella minuta has strong antiobesity potential and can regulate metabolic markers and inhibit de novo lipogenesis to protect against diet-induced obesity.

CELLS (2021)

Review Oncology

Gut-liver axis-mediated mechanism of liver cancer: A special focus on the role of gut microbiota

Naoko Ohtani et al.

Summary: The symbiotic relationship between gut microbiota and the mammalian host is important for digestion of nutrients and production of metabolites. Metabolites such as short-chain fatty acids and secondary bile acids produced by gut bacteria may influence liver function through various mechanisms, including inflammation and DNA damage in the tumor microenvironment. Additionally, components like lipopolysaccharides and lipoteichoic acid from gut bacteria can trigger inflammatory signaling through innate immune receptors.

CANCER SCIENCE (2021)

Article Food Science & Technology

Spirulina platensis polysaccharides attenuate lipid and carbohydrate metabolism disorder in high-sucrose and high-fat diet-fed rats in association with intestinal microbiota

Tian-Tian Li et al.

Summary: Oral administration of Spirulina platensis crude polysaccharides can significantly improve lipid and carbohydrate metabolism disorder in high-sucrose and high-fat diet-fed rats, along with regulating liver mRNA expressions and modulating intestinal microbiota.

FOOD RESEARCH INTERNATIONAL (2021)

Article Multidisciplinary Sciences

High-fat diet-induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide

Woongjae Yoo et al.

Summary: It was found that chronic exposure to a high-fat diet can increase levels of circulating trimethlamine N-oxide, a potentially harmful metabolite generated by gut microbiota.

SCIENCE (2021)

Review Nutrition & Dietetics

Impact of Dietary Lipids on the Reverse Cholesterol Transport: What We Learned from Animal Studies

Bianca Papotti et al.

Summary: Reverse cholesterol transport is a physiological mechanism that protects cells from excessive cholesterol accumulation, while dietary lipids may have detrimental effects on cardiovascular health. This review summarizes the mechanisms of action of different types of dietary lipids on various steps of RCT and provides a critical analysis of data from experimental models to clarify their effects on cardiovascular disease.

NUTRIENTS (2021)

Article Immunology

Gut Bacterial Characteristics of Patients With Type 2 Diabetes Mellitus and the Application Potential

Yanyan Que et al.

Summary: Research shows significant differences in microbial diversity between individuals with type 2 diabetes mellitus (T2DM) and controls, but not in microbial alpha diversity. Various operational taxonomic units (OTUs) and bacterial genera with significant odds ratios for T2DM were identified. The microbial characteristics of T2DM can be applied to other studies, improving detection accuracy and disease specificity for T2DM through training on multiple research studies.

FRONTIERS IN IMMUNOLOGY (2021)

Article Integrative & Complementary Medicine

The Role of Ophiopogonin D in Atherosclerosis: Impact on Lipid Metabolism and Gut Microbiota

Ya-Xin Zhang et al.

Summary: The study demonstrates that OPD treatment significantly reduces the development of atherosclerosis, improves lipid levels and liver steatosis, and decreases the relative abundance of Erysipelotrichaceae genera associated with cholesterol metabolism in gut microbiota. OPD may attenuate atherosclerosis by inhibiting mTOR phosphorylation and lipid metabolism signaling pathways, in addition to altering gut microbiota composition and fecal metabolites.

AMERICAN JOURNAL OF CHINESE MEDICINE (2021)

Review Gastroenterology & Hepatology

Driver-passenger bacteria and their metabolites in the pathogenesis of colorectal cancer

Marion Avril et al.

Summary: Colorectal cancer (CRC) is a significant public health problem globally, with gut microbiota playing an important role in the disease's etiology. Further research is needed to clarify the specific roles of bacteria in CRC development.

GUT MICROBES (2021)

Article Biochemistry & Molecular Biology

The association of serum total bile acid with non-alcoholic fatty liver disease in Chinese adults: a cross sectional study

Ziyu Zhang et al.

LIPIDS IN HEALTH AND DISEASE (2020)

Article Biotechnology & Applied Microbiology

Antibiotics-induced perturbations in gut microbial diversity influence metabolic phenotypes in a murine model of high-fat diet-induced obesity

Dongmin Liu et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2019)

Review Biochemistry & Molecular Biology

Molecular Insights into the Mechanisms Underlying the Cholesterol-Lowering Effects of Phytosterols

Lidia Cedo et al.

CURRENT MEDICINAL CHEMISTRY (2019)

Review Nutrition & Dietetics

Polyphenol Effects on Cholesterol Metabolism via Bile Acid Biosynthesis, CYP7A1: A Review

Karen F. Chambers et al.

NUTRIENTS (2019)

Article Agriculture, Multidisciplinary

Effects of Stigmasterol and β-Sitosterol on Nonalcoholic Fatty Liver Disease in a Mouse Model: A Lipidomic Analysis

Simin Feng et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Intake of stigmasterol and beta-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet

Simin Feng et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2018)

Article Biochemistry & Molecular Biology

Apple Polysaccharide inhibits microbial dysbiosis and chronic inflammation and modulates gut permeability in HFD-fed rats

Sheng Wang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2017)

Article Biochemistry & Molecular Biology

Cholesterol Biosynthesis: A Mechanistic Overview

Nuno M. F. S. A. Cerqueira et al.

BIOCHEMISTRY (2016)

Review Food Science & Technology

Bile Acid Modifications at the Microbe-Host Interface: Potential for Nutraceutical and Pharmaceutical Interventions in Host Health

Susan A. Joyce et al.

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 7 (2016)

Article Gastroenterology & Hepatology

Changes in intestinal barrier function and gut microbiota in high-fat diet-fed rats are dynamic and region dependent

M. Kristina Hamilton et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2015)

Article Cell Biology

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

Evie P. M. Broeders et al.

CELL METABOLISM (2015)

Article Cell Biology

Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance

Mohamed Sham Shihabudeen et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2015)

Article Multidisciplinary Sciences

Diet rapidly and reproducibly alters the human gut microbiome

Lawrence A. David et al.

NATURE (2014)

Article Multidisciplinary Sciences

Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut

Susan A. Joyce et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Food Science & Technology

Effect of pigeon pea (Cajanus cajan L.) on high-fat diet-induced hypercholesterolemia in hamsters

Fan-Jhen Dai et al.

FOOD AND CHEMICAL TOXICOLOGY (2013)

Article Gastroenterology & Hepatology

Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1-/- mice fed low levels of cholic acid

Ryan D. Jones et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2012)

Review Immunology

Regulation of epithelial immunity by IL-17 family cytokines

Rajita Pappu et al.

TRENDS IN IMMUNOLOGY (2012)

Article Biochemistry & Molecular Biology

Macrophage activation and polarization

Fernando Oneissi Martinez et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2008)

Review Biotechnology & Applied Microbiology

Targeting bile-acid signalling for metabolic diseases

Charles Thomas et al.

NATURE REVIEWS DRUG DISCOVERY (2008)