Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 9, Issue 20, Pages 5530-5535Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2qo01082h
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- Youth Innovation and Technology Project of High School in Shandong Province [2019KJC021]
- Natural Science Foundation of Shandong Province [ZR2021MB065]
- CAS Light of West China Program
- Qinghai Province Innovation Platform Construction Project [2022-ZJ-Y03]
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A visible-light-mediated strategy for the synthesis of multisubstituted pyrazoles through a three-component carbene transfer reaction of alpha-diazoesters with cyclic ethers and pyrazolones is reported. This transformation can be achieved under mild and additive-free conditions, yielding a wide range of multisubstituted pyrazoles with moderate to good yields and excellent functional group compatibility. Additionally, a series of substituted 1,3-dicarbonyl derivatives can be conveniently obtained via visible-light-promoted three-component reaction of alpha-diazoesters, cyclic ethers, and 1,3-dicarbonyl compounds.
A visible-light-mediated strategy is reported for the efficient synthesis of multisubstituted pyrazoles through a three-component carbene transfer reaction of alpha-diazoesters with cyclic ethers and pyrazolones. The present transformation could be accomplished under mild and additive-free conditions to afford a wide range of multisubstituted pyrazoles with moderate to good yields and excellent functional group compatibility. It is noteworthy that a series of substituted 1,3-dicarbonyl derivatives were also conveniently obtained via visible-light-promoted three-component reaction of alpha-diazoesters, cyclic ethers, and 1,3-dicarbonyl compounds.
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