Journal
TECHNICAL PHYSICS
Volume 67, Issue 4, Pages 277-282Publisher
PLEIADES PUBLISHING INC
DOI: 10.1134/S1063784222050103
Keywords
delivery systems; doxorubicin; scanning electron microscopy; transmission electron microscopy; high performance liquid chromatography
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Funding
- Institute of Macromolecular Compounds, RAS [AAA-A20-120022090044-2]
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The structural and functional characteristics of various systems for delivering the antitumor drug doxorubicin were compared in this study. It was found that there were significant differences in the penetration of carriers of different sizes into the bloodstream.
Structural and functional characteristics of various systems for delivery of antitumor preparation doxorubicin were compared. Two types of delivery systems were studied: submicron porous calcium carbonate cores coated with a polyanion (sodium dextran sulfate) and nanoparticles based on random amphiphilic copolymers of different amino acids. Scanning and transmission electron microscopy, dynamic light scattering were used to determine sizes of both delivery systems and electrokinetic potentials of their surfaces. Toxicity of delivery systems containing from 0 to 5 mu g/mL of doxorubicin against MCF7 tumor cells was determined from the results of measurements of electric impedance of microsensors in the unit containing the cells and the tested delivery systems. Time-concentration profiles of doxorubicin in rat blood plasma after intraperitoneal administration of the tested delivery systems were obtained by high performance liquid chromatography. These profiles indicate considerable differences in the processes of penetration of carriers of various sizes into bloodstream.
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