Journal
CHEMICAL COMMUNICATIONS
Volume 58, Issue 74, Pages 10392-10395Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc04084k
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Funding
- National Natural Science Foundation of China [22177094, 22174117]
- Applied Basic Research of Sichuan Province [2021YJ0397]
- Fundamental Research Funds for the Central University [2682021 ZTPY039]
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An AIE-active furo[2,3-c]pyridine-based photosensitizer, LIQ-TF, was synthesized through Rh-catalyzed tandem reaction. LIQ-TF exhibited near-infrared emission with high quantum yield, and high efficiency in generating O-1(2) and (OH)-O-center dot, which could be used for specific imaging and photodynamic ablation of Gram-positive bacteria in vitro and in vivo, demonstrating great potential for combating multiple drug-resistant bacteria.
An Rh-catalyzed tandem reaction was performed to construct an AIE-active furo[2,3-c]pyridine-based photosensitizer, named LIQ-TF. LIQ-TF showed near-infrared emission with high quantum yield, and high O-1(2) and (OH)-O-center dot generation efficiency, and could be used for specific imaging and photodynamic ablation of Gram-positive bacteria in vitro and in vivo, showing great potential for combating multiple drug-resistant bacteria.
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