4.8 Article

In-water synthesis of isocyanides under micellar conditions

Journal

GREEN CHEMISTRY
Volume 24, Issue 18, Pages 7022-7028

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d2gc01398c

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Funding

  1. Universita del Piemonte Orientale, Novara
  2. Universita degli Studi di Napoli Federico II

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An environmentally friendly method for the preparation of aliphatic isocyanides under anhydrous conditions using micellar systems at room temperature is reported. The substitution of undesirable components in the traditional reaction makes this transformation more sustainable and safe.
An in-water dehydration of N-formamides to afford isocyanides using micellar conditions at room temperature is reported. This method allows for the preparation of aliphatic isocyanides in an environmental friendly manner. The replacement of undesirable components such as phosphorous oxychloride, triethyl amine and dichloromethane (the classical combination used for the dehydration of N-formamides), by p-toluen sulphonyl chloride, sodium hydrogen carbonate and water makes this transformation really sustainable and safe.

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