HyperArc™ Dosimetric Validation for Multiple Targets Using Ionization Chamber and RT-100 Polymer Gel

Multiple brain metastases single-isocenter stereotactic radiosurgery (SRS) treatment is increasingly employed in radiotherapy department. Before its use in clinical routine, it is recommended to perform end-to-end tests. In this work, we report the results of five HyperArc (TM) treatment plans obtained by both ionization chamber (IC) and polymer gel. The end-to-end tests were performed using a water equivalent Mobius Verification Phantom (TM) (MVP) and a 3D-printed anthropomorphic head phantom PseudoPatient (R) (PP) (RTsafe P.C., Athens, Greece); 2D and 3D dose distributions were evaluated on the PP phantom using polymer gel (RTsafe). Gels were read by 1.5T magnetic resonance imaging (MRI). Comparison between calculated and measured distributions was performed using gamma index passing rate evaluation by different criteria (5% 2 mm, 3% 2 mm, 5% 1 mm). Mean point dose differences of 1.01% [min -0.77%-max 2.89%] and 0.23% [min 0.01%-max 2.81%] were found in MVP and PP phantoms, respectively. For each target volume, the obtained results in terms of gamma index passing rate show an agreement >95% with 5% 2 mm and 3% 2 mm criteria for both 2D and 3D distributions. The obtained results confirmed that the use of a single isocenter for multiple lesions reduces the treatment time without compromising accuracy, even in the case of target volumes that are quite distant from the isocenter.

Automated summary

Before performing multiple brain metastases single-isocenter stereotactic radiosurgery (SRS) treatment, it is recommended to conduct end-to-end tests. In this study, the results of the tests using ionization chamber (IC) and polymer gel were reported. The findings showed that using a single isocenter for multiple lesions can reduce treatment time without compromising accuracy.