Journal
ORGANIC & BIOMOLECULAR CHEMISTRY
Volume 20, Issue 36, Pages 7278-7283Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ob01443b
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Funding
- National Natural Science Foundation of China [81872762, 22177139, 21961142008]
- Fundamental Research Funds for the Central Universities, South-Central Minzu University [CZP21001]
- Thailand Research Fund [DBG6280008]
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Antroxazole A (1), a chamigrane type sesquiterpene dimer containing an oxazole moiety, was isolated from cultures of the fungus Antrodiella albocinnamomea. It exhibited specific inhibition against LPS-induced proliferation of B lymphocyte cells.
Antroxazole A (1), a chamigrane type sesquiterpene dimer containing an oxazole moiety, has been characterized from cultures of the fungus Antrodiella albocinnamomea. The structure with absolute configuration was determined by extensive spectroscopic methods and single crystal X-ray diffraction. A plausible biosynthetic pathway for 1 was proposed. Compound 1 exhibits inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with an IC50 value of 16.3 mu M.
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