Fluorine in metal-catalyzed asymmetric transformations: the lightest halogen causing a massive effect

This review aims at providing an overview of the most significant applications of fluorine-containing ligands reported in the literature starting from 2001 until mid-2021. The ligands are classified according to the nature of the donor atoms involved. This review highlights both metal-ligand interactions and the structure-reactivity relationships resulting from the presence of the fluorine atom or fluorine-containing substituents on chiral catalysts.

Automated summary

This review provides an overview of the significant applications of fluorine-containing ligands reported in literature from 2001 to mid-2021. The ligands are classified based on the nature of donor atoms involved. The review highlights metal-ligand interactions and the structure-reactivity relationships resulting from the presence of fluorine atom or fluorine-containing substituents on chiral catalysts.