Journal
RSC ADVANCES
Volume 12, Issue 38, Pages 24930-24934Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2ra03681a
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Funding
- National Natural Science Foundation of China (NSFC) [21801075, 22001165]
- Shanghai Jiao Tong University
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The palladium-catalyzed oxidative C-H olefinations of uridine, deoxyuridine, uridine monophosphate and uridine analogues are reported. This protocol offers an efficient, atom-economic, and environmentally friendly approach for synthesizing biologically important C5-alkene modified uracil/uridine-containing derivatives and pharmaceutical candidates.
The palladium-catalyzed oxidative C-H olefinations of uridine, deoxyuridine, uridine monophosphate and uridine analogues are reported herein. This protocol provides an efficient, atom-economic and environmentally friendly approach to the synthesis of biologically important C5-alkene modified uracil/uridine-containing derivatives and pharmaceutical candidates.
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